Accelerated in Vivo Cardiac Diffusion-Tensor MRI Using Residual Deep Learning-based Denoising in Participants with Obesity.

Autor:	Phipps K; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., van de Boomen M; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Eder R; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Michelhaugh SA; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Spahillari A; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Kim J; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Parajuli S; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Reese TG; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Mekkaoui C; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Das S; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Gee D; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Shah R; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Sosnovik DE; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass., Nguyen C; Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, 4.213, Charlestown, MA 02129 (K.P., M.v.d.B., R.E., J.K., S.P., S.D., R.S., D.E.S., C.N.); Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (M.v.d.B.); A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass (M.v.d.B., T.G.R., C.M., D.E.S., C.N.); Cardiology Division (S.A.M., A.S., S.D., R.S., D.E.S.) and Weight Center (D.G.), Massachusetts General Hospital, Boston, Mass; and Departments of Radiology (T.G.R., C.M.), Medicine (S.D., R.S., D.E.S., C.N.), and Surgery (D.G.), Harvard Medical School, Boston, Mass.
Jazyk:	angličtina
Zdroj:	Radiology. Cardiothoracic imaging [Radiol Cardiothorac Imaging] 2021 Jun 24; Vol. 3 (3), pp. e200580. Date of Electronic Publication: 2021 Jun 24 (Print Publication: 2021).
DOI:	10.1148/ryct.2021200580
Abstrakt:	Purpose: To develop and assess a residual deep learning algorithm to accelerate in vivo cardiac diffusion-tensor MRI (DT-MRI) by reducing the number of averages while preserving image quality and DT-MRI parameters. Materials and Methods: In this prospective study, a denoising convolutional neural network (DnCNN) for DT-MRI was developed; a total of 26 participants, including 20 without obesity (body mass index [BMI] < 30 kg/m 2 ; mean age, 28 years ± 3 [standard deviation]; 11 women) and six with obesity (BMI ≥ 30 kg/m 2 ; mean age, 48 years ± 11; five women), were recruited from June 19, 2019, to July 29, 2020. DT-MRI data were constructed at four averages (4Av), two averages (2Av), and one average (1Av) without and with the application of the DnCNN (4Av DnCNN , 2Av DnCNN , 1Av DnCNN ). All data were compared against the reference DT-MRI data constructed at eight averages (8Av). Image quality, characterized by using the signal-to-noise ratio (SNR) and structural similarity index (SSIM), and the DT-MRI parameters of mean diffusivity (MD), fractional anisotropy (FA), and helix angle transmurality (HAT) were quantified. Results: No differences were found in image quality or DT-MRI parameters between the accelerated 4Av DnCNN DT-MRI and the reference 8Av DT-MRI data for the SNR (29.1 ± 2.7 vs 30.5 ± 2.9), SSIM (0.97 ± 0.01), MD (1.3 µm 2 /msec ± 0.1 vs 1.31 µm 2 /msec ± 0.11), FA (0.32 ± 0.05 vs 0.30 ± 0.04), or HAT (1.10°/% ± 0.13 vs 1.11°/% ± 0.09). The relationship of a higher MD and lower FA and HAT in individuals with obesity compared with individuals without obesity in reference 8Av DT-MRI measurements was retained in 4Av DnCNN and 2Av DnCNN DT-MRI measurements but was not retained in 4Av or 2Av DT-MRI measurements. Conclusion: Cardiac DT-MRI can be performed at an at least twofold-accelerated rate by using DnCNN to preserve image quality and DT-MRI parameter quantification. Keywords: Adults, Cardiac, Obesity, Technology Assessment, MR-Diffusion Tensor Imaging, Heart, Tissue Characterization Supplemental material is available for this article. © RSNA, 2021. Competing Interests: Disclosures of Conflicts of Interest: K.P. disclosed no relevant relationships. M.v.d.B. disclosed no relevant relationships. R.E. disclosed no relevant relationships. S.A.M. disclosed no relevant relationships. A.S. disclosed no relevant relationships. J.K. disclosed no relevant relationships. S.P. disclosed no relevant relationships. T.G.R. disclosed no relevant relationships. C.M. disclosed no relevant relationships. S.D. Activities related to the present article: author’s institution has research funding from the American Heart Association (AHA). Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships. D.G. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: author is on medical advisory boards for New View Surgical and Boston Scientific; author received consultancy fees from Ethicon, Medtronic, and Boston Scientific. Other relationships: disclosed no relevant relationships. R.S. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: author received consultancy fees from Myokardia, Best Doctors, and Amgen; author’s spouse works at Wolters Kluwer UpToDate; author’s institution has grants/grants pending from AHA and National Institutes of Health (NIH); author has patents for exRNA signatures of cardiac remodeling; author has Pfizer stock and had Gilead stock, which has been sold. Other relationships: disclosed no relevant relationships. D.E.S. Activities related to the present article: author has grant from NIH. Activities not related to the present article author has grants/grants pending from NIH; author’s institution has patents with Mass General Brigham, with no money received. Other relationships: disclosed no relevant relationships. C.N. Activities related to the present article: author’s institution has grant from NIH. Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships. (2021 by the Radiological Society of North America, Inc.)
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