Cost comparison between botulinum neurotoxin and surgery in the treatment of infantile esotropia in a tertiary public hospital.

Autor:	Mayet I; Department of Neurosciences, Division of Ophthalmology, University of the Witwatersrand, Johannesburg-Braamfontein, South Africa., McGee SA; South African Medical Association, Pretoria, South Africa., Ally N; Department of Neurosciences, Division of Ophthalmology, University of the Witwatersrand, Johannesburg-Braamfontein, South Africa., Alli HD; Department of Neurosciences, Division of Ophthalmology, University of the Witwatersrand, Johannesburg-Braamfontein, South Africa., Tikly M; Dept of Rheuamatology, University of the Witwatersrand Faculty of Health Sciences, Johannesburg, South Africa., Williams SE; Department of Neurosciences, Division of Ophthalmology, University of the Witwatersrand, Johannesburg-Braamfontein, South Africa.
Jazyk:	angličtina
Zdroj:	BMJ open ophthalmology [BMJ Open Ophthalmol] 2021 Jun 21; Vol. 6 (1), pp. e000766. Date of Electronic Publication: 2021 Jun 21 (Print Publication: 2021).
DOI:	10.1136/bmjophth-2021-000766
Abstrakt:	Objective: To compare the cost implications of botulinum neurotoxin (BNT) injection to surgery in infantile esotropia (IE) in a public/government funded hospital. Methods and Analysis: A simple costing comparison was undertaken for a randomised clinical trial in IE. Patients were randomised to receive either BNT or standard surgery. The participants in the BNT arm were further subdivided into subgroups based on their age in months and degree of esotropia in prism dioptres (PD) at presentation: G1 ≤60 PD/24 months, G2 ≤24 months/>60 PD, G3 >24 months/≤60 PD, G4 >24 months/>60 PD. The costs were calculated for each arm from primary treatment to eventual satisfactory outcome defined as orthophoria or microtropia (≤10 PD). A bottom-up costing analysis was done for single and multiple procedures for each arm. Comprehensive variable costs as well as fixed costs were calculated at each point of intervention and expressed in local currency ZAR (US$1=ZAR15.00). Costing was analysed for surgery and BNT subgroups (based on clinical success). Results: There were 101 patients enrolled in the trial. 54 in the BNT arm and 47 in the surgery arm. Cost for single surgery and single BNT was ZAR 7743.04 and 1713.14, respectively. A favourable clinical outcome was achieved in 72% of surgery arm and 37% of BNT arm. The mean cost for eventual favourable outcome in BNT arm was ZAR9158.08 and in surgery arm ZAR9124.27 (p=0.26). Mean cost in G1 was ZAR6328.45, in G2 ZAR7197.45, in G3 ZAR11891.93 and G4 ZAR12882.44 (p=0.018). Conclusion: BNT has a cost-benefit in IE and is a viable option in the primary treatment of IE in resource constrained regions. Clinical outcomes and economic benefit in smaller angle of esotropia and younger patients are comparable to surgery. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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