COVID-19 and aging: Identifying measures of severity.

Autor:	Neves MT; Department of Medical Oncology Hospital São Francisco Xavier, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal., de Matos LV; Department of Medical Oncology Hospital São Francisco Xavier, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal., Vasques AC; Department of Medical Oncology Hospital São Francisco Xavier, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal., Sousa IE; Department of Internal Medicine, Hospital São Francisco Xavier, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal., Ferreira I; Department of Internal Medicine, Hospital São Francisco Xavier, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal., Peres S; Department of Infectious Diseases, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal., Jesus S; Department of Internal Medicine, Hospital São Francisco Xavier, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal., Fonseca C; Department of Internal Medicine, Hospital São Francisco Xavier, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal., Mansinho K; Department of Infectious Diseases, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.
Jazyk:	angličtina
Zdroj:	SAGE open medicine [SAGE Open Med] 2021 Jun 24; Vol. 9, pp. 20503121211027462. Date of Electronic Publication: 2021 Jun 24 (Print Publication: 2021).
DOI:	10.1177/20503121211027462
Abstrakt:	Introduction: We aimed to compare clinical features of older age group and young and middle-aged patients with COVID-19 and analyze mortality predictors. Methods: Retrospective analysis of ongoing collection of prespecified data, on a single institution, including patients hospitalized consecutively due to COVID-19 infection, from March to June 2020. Results: Of 195 patients, 56.9% were ⩾65 years (older age group). Older age group had multimorbidity ( p  < 0.001). At admission Early Warning Score-2 ( p  < 0.001), C-reactive protein, D-dimer, creatinine, anemia and lymphopenia were higher in older age group, as well as median time of hospitalization (14 vs 10 days, p  = 0.004). Complications were more common in older age group, but there were no significant differences in admission to intensive care. There were 18 deaths, 16 in older age group. Modified Early Warning Score at admission (odds ratio = 1.60, 95% confidence interval = 1.07-1.37, p  = 0.021) and C-reactive protein >5 mg/dL (odds ratio = 2.12, 95% confidence interval = 1.13-26.26, p  = 0.034) were independent predictors of inhospital mortality in older age group but not in young and middle-aged. Conclusion: Older age group was at higher risk for complications and inhospital mortality. Identification of specific scores of severity for this population is essential to ensure that best care is provided. Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s) 2021.)
Databáze:	MEDLINE
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