Case Report: The first familial hCG syndrome in a Chinese family.

Autor:	Hung LY; Chemical Pathology Laboratory, Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.; Chemical Pathology Laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong., Leung MT; Chemical Pathology Laboratory, Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong., Chan TC; Chemical Pathology Laboratory, Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong., Cheung HN; Chemical Pathology Laboratory, Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong., Li WH; Department of Obstetrics & Gynaecology, Queen Elizabeth Hospital, Kowloon, Hong Kong., Cheung YS; Department of Obstetrics & Gynaecology, Queen Elizabeth Hospital, Kowloon, Hong Kong., Wong AS; Department of Obstetrics & Gynaecology, Queen Elizabeth Hospital, Kowloon, Hong Kong., Shek CC; Chemical Pathology Laboratory, Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong., Chen SP; Chemical Pathology Laboratory, Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Jazyk:	angličtina
Zdroj:	F1000Research [F1000Res] 2021 Jun 08; Vol. 10, pp. 458. Date of Electronic Publication: 2021 Jun 08 (Print Publication: 2021).
DOI:	10.12688/f1000research.53636.1
Abstrakt:	Familial hCG syndrome is a rare and benign cause of elevated serum beta human chorionic gonadotropin (hCG). We present here a case of familial hCG syndrome diagnosed in a Hong Kong Chinese family, which we believe to be the first reported in Chinese. A 38-year-old woman presented with incidental finding of persistently elevated hCG, analytically confirmed both in urine and blood. Extensive radiological and biochemical work-up were performed but were negative for pregnancy and malignancy. Testing of another asymptomatic family member revealed unexplained elevation of serum hCG, confirming the diagnosis of familial hCG syndrome. Knowledge and awareness of this entity among clinicians are important to avoid unnecessary investigations and treatment in affected families. Competing Interests: No competing interests were disclosed. (Copyright: © 2021 Hung LY et al.)
Databáze:	MEDLINE
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