Infection of expanded polytetrafluoroethylene and Dacron-coated stents with Staphylococcus epidermidis : an experimental study in pigs.
| Autor: | Dutra CF; Universidade de Caxias do Sul - UCS, Caxias do Sul, RS, Brasil., Pereira AH; Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brasil., Wollheim C; Universidade de Caxias do Sul - UCS, Caxias do Sul, RS, Brasil., Pongiluppi R; Universidade de Caxias do Sul - UCS, Caxias do Sul, RS, Brasil., Fellini R; Universidade de Caxias do Sul - UCS, Caxias do Sul, RS, Brasil., Gomes SV; Universidade de Caxias do Sul - UCS, Caxias do Sul, RS, Brasil., Nonemacher H; Hospital Santa Mônica Erechim, Erechim, RS, Brasil. |
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| Jazyk: | angličtina |
| Zdroj: | Jornal vascular brasileiro [J Vasc Bras] 2021 Jun 25; Vol. 20, pp. e20200157. Date of Electronic Publication: 2021 Jun 25 (Print Publication: 2021). |
| DOI: | 10.1590/1677-5449.200157 |
| Abstrakt: | Background: Diagnosis of the etiologic agent of endoprosthesis infections is essential to enable treatment, since these infections constitute important complications of endovascular procedures. Sonication of explanted tissue and materials is a technique that can be used to facilitate detection of biofilm-producing bacteria. Objectives: To evaluate infection of pigs' aortas after implantation of nitinol stents coated with polytetrafluoroethylene (ePTFE) or Dacron, previously infected with biofilm-producing Staphylococcus epidermidis . Intimal thickening and the inflammatory response in the aortic wall were also evaluated. Methods: 11 ePTFE-coated nitinol stents and 10 Dacron stents infected with S. epidermidis strains were implanted in the infrarenal aorta of 21 8-week-old pigs. After 2 weeks, the aorta containing the stents was removed. A vortex mixer and ultrasound were used to homogenize the samples and remove the biofilm. Subsequently, the number of colony-forming units was counted. Results: There were no significant differences between the two groups in terms of the number of colony-forming units or of inflammation in the arterial wall. With the exception of one specimen from the Dacron group, all aortic stent cultures were positive for S. epidermidis . Conclusions: There were no significant differences in the inflammatory response or infection rate between ePTFE and Dacron-coated stents actively infected with biofilm-producing S. epidermidis . Intimal thickening and the inflammatory response to infection of endoprostheses were similar. These results suggest that the two most widely used stent lining materials have a similar infection rate. Competing Interests: Conflicts of interest:No conflicts of interest declared concerning the publication of this article. (Copyright© 2021 The authors.) |
| Databáze: | MEDLINE |
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