Case Report: Sars-CoV-2 Infection in a Vaccinated Individual: Evaluation of the Immunological Profile and Virus Transmission Risk.

Autor:	Strafella C; Genomic Medicine Laboratory UILDM, IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy., Caputo V; Genomic Medicine Laboratory UILDM, IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy., Guerrera G; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, Italy., Termine A; Genomic Medicine Laboratory UILDM, IRCCS Santa Lucia Foundation, Rome, Italy., Fabrizio C; Genomic Medicine Laboratory UILDM, IRCCS Santa Lucia Foundation, Rome, Italy., Cascella R; Genomic Medicine Laboratory UILDM, IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy., Picozza M; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, Italy., Caltagirone C; Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Rossini A; Medical Services, IRCCS Santa Lucia Foundation, Rome, Italy., Balice MP; Clinical Microbiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Salvia A; Medical Services, IRCCS Santa Lucia Foundation, Rome, Italy., Battistini L; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, Italy., Borsellino G; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, Italy., Giardina E; Genomic Medicine Laboratory UILDM, IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2021 Jun 23; Vol. 12, pp. 708820. Date of Electronic Publication: 2021 Jun 23 (Print Publication: 2021).
DOI:	10.3389/fimmu.2021.708820
Abstrakt:	During the COVID19 pandemic, a range of vaccines displayed high efficacy in preventing disease, severe outcomes of infection, and mortality. However, the immunological correlates of protection, the duration of immune response, the transmission risk over time from vaccinated individuals are currently under active investigation. In this brief report, we describe the case of a vaccinated Healthcare Professional infected with a variant of Sars-CoV-2, who has been extensively investigated in order to draw a complete trajectory of infection. The patient has been monitored for the whole length of infection, assessing the temporal viral load decay, the quantification of viral RNA and subgenomic mRNA, antibodies (anti Sars-CoV-2, IgA, IgG, IgM) and cell-mediated (cytokine, B- and T-cell profiles) responses. Overall, this brief report highlights the efficacy of vaccine in preventing COVID19 disease, accelerating the recovery from infection, reducing the transmission risk, although the use of precautionary measures against Sars-CoV-2 spreading still remain critical. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Strafella, Caputo, Guerrera, Termine, Fabrizio, Cascella, Picozza, Caltagirone, Rossini, Balice, Salvia, Battistini, Borsellino and Giardina.)
Databáze:	MEDLINE
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