Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis.

Autor:	Sumner JA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, United States., Maihofer AX; Department of Psychiatry, University of California, San Diego, San Diego, CA, United States.; Veterans Affairs San Diego Healthcare System, VA Center of Excellence for Stress and Mental Health (CESAMH), San Diego, CA, United States., Michopoulos V; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States.; Yerkes National Primate Research Center, Atlanta, GA, United States., Rothbaum AO; Department of Psychological Sciences, Case Western Reserve University, Cleveland, OH, United States., Almli LM; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States., Andreassen OA; NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Ashley-Koch AE; Duke Molecular Physiology Institute, Duke University, Durham, NC, United States., Baker DG; Department of Psychiatry, University of California, San Diego, San Diego, CA, United States.; Veterans Affairs San Diego Healthcare System, VA Center of Excellence for Stress and Mental Health (CESAMH), San Diego, CA, United States., Beckham JC; Durham VA Health Care System, Durham, NC, United States.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, United States., Bradley B; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States.; Atlanta VA Health Care System, Decatur, GA, United States., Breen G; Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; NIHR BRC at the Maudsley, King's College London, London, United Kingdom., Coleman JRI; Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; NIHR BRC at the Maudsley, King's College London, London, United Kingdom., Dale AM; Department of Radiology, University of California, San Diego, San Diego, CA, United States.; Department of Neurosciences, University of California, San Diego, San Diego, CA, United States., Dennis MF; Durham VA Health Care System, Durham, NC, United States.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, United States., Feeny NC; Department of Psychological Sciences, Case Western Reserve University, Cleveland, OH, United States., Franz CE; Department of Psychiatry, University of California, San Diego, San Diego, CA, United States., Garrett ME; Duke Molecular Physiology Institute, Duke University, Durham, NC, United States., Gillespie CF; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States., Guffanti G; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; McLean Hospital, Belmont, MA, United States., Hauser MA; Duke Molecular Physiology Institute, Duke University, Durham, NC, United States., Hemmings SMJ; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Faculty of Medicine & Health Sciences, Stellenbosch University, Cape Town, South Africa., Jovanovic T; Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI, United States., Kimbrel NA; Durham VA Health Care System, Durham, NC, United States.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, United States., Kremen WS; Department of Psychiatry, University of California, San Diego, San Diego, CA, United States.; Veterans Affairs San Diego Healthcare System, VA Center of Excellence for Stress and Mental Health (CESAMH), San Diego, CA, United States., Lawford BR; School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD, Australia., Logue MW; National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, United States.; Department of Psychiatry, Boston University School of Medicine, Boston, MA, United States.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States.; Biomedical Genetics, Boston University School of Medicine, Boston, MA, United States., Lori A; Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, United States., Lyons MJ; Department of Psychological & Brain Sciences, Boston University, Boston, MA, United States., Maples-Keller J; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States., Mavissakalian MR; Department of Psychiatry, Case Western Reserve University, Cleveland, OH, United States., McGlinchey RE; GRECC/TRACTS, VA Boston Healthcare System, Boston, MA, United States., Mehta D; Center for Genomics and Personalised Health, Queensland University of Technology, Kelvin Grove, QLD, Australia., Mellor R; Gallipoli Medical Research Foundation, Greenslopes Private Hospital, Brisbane, QLD, Australia., Milberg W; GRECC/TRACTS, VA Boston Healthcare System, Boston, MA, United States., Miller MW; National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, United States.; Department of Psychiatry, Boston University School of Medicine, Boston, MA, United States., Morris CP; School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD, Australia., Panizzon MS; Department of Psychiatry, University of California, San Diego, San Diego, CA, United States., Ressler KJ; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States.; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.; McLean Hospital, Belmont, MA, United States., Risbrough VB; Department of Psychiatry, University of California, San Diego, San Diego, CA, United States.; Veterans Affairs San Diego Healthcare System, VA Center of Excellence for Stress and Mental Health (CESAMH), San Diego, CA, United States., Rothbaum BO; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States., Roy-Byrne P; Department of Psychology, University of Washington, Seattle, WA, United States., Seedat S; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Faculty of Medicine & Health Sciences, Stellenbosch University, Cape Town, South Africa., Smith AK; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States.; Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, United States., Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States., van den Heuvel LL; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Faculty of Medicine & Health Sciences, Stellenbosch University, Cape Town, South Africa., Voisey J; School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD, Australia.; Center for Genomics and Personalised Health, Queensland University of Technology, Kelvin Grove, QLD, Australia., Young RM; School of Psychology and Counseling, Queensland University of Technology, Kelvin Grove, QLD, Australia., Zoellner LA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States., Nievergelt CM; Department of Psychiatry, University of California, San Diego, San Diego, CA, United States.; Veterans Affairs San Diego Healthcare System, VA Center of Excellence for Stress and Mental Health (CESAMH), San Diego, CA, United States., Wolf EJ; National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, United States.; Department of Psychiatry, Boston University School of Medicine, Boston, MA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2021 Jun 23; Vol. 15, pp. 678503. Date of Electronic Publication: 2021 Jun 23 (Print Publication: 2021).
DOI:	10.3389/fnins.2021.678503
Abstrakt:	Growing research suggests that posttraumatic stress disorder (PTSD) may be a risk factor for poor cardiovascular health, and yet our understanding of who might be at greatest risk of adverse cardiovascular outcomes after trauma is limited. In this study, we conducted the first examination of the individual and synergistic contributions of PTSD symptoms and blood pressure genetics to continuous blood pressure levels. We harnessed the power of the Psychiatric Genomics Consortium-PTSD Physical Health Working Group and investigated these associations across 11 studies of 72,224 trauma-exposed individuals of European ( n = 70,870) and African ( n = 1,354) ancestry. Genetic contributions to blood pressure were modeled via polygenic scores (PGS) for systolic blood pressure (SBP) and diastolic blood pressure (DBP) that were derived from a prior trans-ethnic blood pressure genome-wide association study (GWAS). Results of trans-ethnic meta-analyses revealed significant main effects of the PGS on blood pressure levels [SBP: β = 2.83, standard error (SE) = 0.06, p < 1E-20; DBP: β = 1.32, SE = 0.04, p < 1E-20]. Significant main effects of PTSD symptoms were also detected for SBP and DBP in trans-ethnic meta-analyses, though there was significant heterogeneity in these results. When including data from the largest contributing study - United Kingdom Biobank - PTSD symptoms were negatively associated with SBP levels (β = -1.46, SE = 0.44, p = 9.8E-4) and positively associated with DBP levels (β = 0.70, SE = 0.26, p = 8.1E-3). However, when excluding the United Kingdom Biobank cohort in trans-ethnic meta-analyses, there was a nominally significant positive association between PTSD symptoms and SBP levels (β = 2.81, SE = 1.13, p = 0.01); no significant association was observed for DBP (β = 0.43, SE = 0.78, p = 0.58). Blood pressure PGS did not significantly moderate the associations between PTSD symptoms and blood pressure levels in meta-analyses. Additional research is needed to better understand the extent to which PTSD is associated with high blood pressure and how genetic as well as contextual factors may play a role in influencing cardiovascular risk. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Sumner, Maihofer, Michopoulos, Rothbaum, Almli, Andreassen, Ashley-Koch, Baker, Beckham, Bradley, Breen, Coleman, Dale, Dennis, Feeny, Franz, Garrett, Gillespie, Guffanti, Hauser, Hemmings, Jovanovic, Kimbrel, Kremen, Lawford, Logue, Lori, Lyons, Maples-Keller, Mavissakalian, McGlinchey, Mehta, Mellor, Milberg, Miller, Morris, Panizzon, Ressler, Risbrough, Rothbaum, Roy-Byrne, Seedat, Smith, Stevens, van den Heuvel, Voisey, Young, Zoellner, PGC-PTSD Physical Health Working Group, Nievergelt and Wolf.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu