The significance of blood and salivary oxidative stress markers and chemerin in gestational diabetes mellitus.
| Autor: | Bulut A; Cyprus International University Faculty of Dentistry, Nicosia, Turkish Republic of Northern Cyprus. Electronic address: draysebulut@gmail.com., Akca G; Department of Medical Microbiology, Gazi University Faculty of Dentistry, Ankara, Turkey., Keskin Aktan A; School of Medicine, Department of Physiology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey., Akbulut KG; Department of Physiology, Gazi University Faculty of Medicine, Ankara, Turkey., Babül A; Department of Physiology, Gazi University Faculty of Medicine, Ankara, Turkey. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Taiwanese journal of obstetrics & gynecology [Taiwan J Obstet Gynecol] 2021 Jul; Vol. 60 (4), pp. 695-699. |
| DOI: | 10.1016/j.tjog.2021.05.019 |
| Abstrakt: | Objective: Gestational diabetes mellitus (GDM) is a medical complication of pregnancy. The aim of this study was to evaluate the correlations between the salivary and blood levels of oxidative stress markers and an adipokine chemerin, which play a role in the pathogenesis of GDM. Materials and Methods: Study groups (Control (n = 29), GDM (n = 22)) had been assessed clinically healthy oral hygiene, according to the age range between 25 and 40 years, BMI<30 kg/m2, who were non-smokers and who were not having systemic diseases. GDM was diagnosed using a 100 g OGTT. Saliva samples were collected without stimulation between 08.30 and 10.00 a.m.. Chemerin and TrxR levels were measured by ELISA. Malondialdehyde, sulfhydryl and NO levels were determined by spectrophotometric analysis. Statistical analysis were performed by Shapiro Wilk, Mann Whitney U, Student's t test. Results: Blood pressure, BMI, and plasma chemerin, salivary chemerin, fasting glucose, LDL, triglyceride, CRP levels in GDM were not different when compared to Control. There were significant differences between Plasma TrxR and HDL levels. Also, significant differences between salivary TrxR and Malondialdehyde levels were observed in GDM. Conclusion: It was concluded that the optimal cut-off points for oxidative stress parameters and chemerin level can be used to distinguish between healthy pregnant and GDM. Competing Interests: Declaration of competing interest The authors declare that there is no conflict of interest. (Copyright © 2021. Published by Elsevier B.V.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|