Atherosclerotic Vascular Disease Associated with Chronic Kidney Disease.
| Autor: | Tunbridge MJ; Nephrology Department, Royal Brisbane and Women's Hospital, Level 9 Ned Hanlon Building, Butterfield Street, Herston, QLD 4029, Australia; University of Queensland, Mayne Medical Building, 288 Herston Road, Herston, QLD 4029, Australia., Jardine AG; University of Queensland, Mayne Medical Building, 288 Herston Road, Herston, QLD 4029, Australia; Institute of Cardiovascular and Medical Sciences, University of Glasgow, BHF GCRC 126 University Place, Glasgow G12 8TA, UK. Electronic address: alan.jardine@glasgow.ac.uk. |
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| Jazyk: | angličtina |
| Zdroj: | Cardiology clinics [Cardiol Clin] 2021 Aug; Vol. 39 (3), pp. 403-414. |
| DOI: | 10.1016/j.ccl.2021.04.011 |
| Abstrakt: | Cardiovascular risk increases as glomerular filtration rate (GFR) declines in progressive renal disease and is maximal in patients with end-stage renal disease requiring maintenance dialysis. Atherosclerotic vascular disease, for which hyperlipidemia is the main risk factor and lipid-lowering therapy is the key intervention, is common. However, the pattern of dyslipidemia changes with low GFR and the association with vascular events becomes less clear. While the pathophysiology and management of patients with early chronic kidney disease (CKD) is similar to the general population, advanced and end-stage CKD is characterized by a disproportionate increase in fatal events, ineffectiveness of statin therapy, and greatly increased risk associated with coronary interventions. The most effective strategies to reduce atherosclerotic cardiovascular disease in CKD are to slow the decline in renal function or to restore renal function by transplantation. Competing Interests: Disclosure Competing interests: Dr A.G. Jardine has received consulting fees from Novartis, AstraZeneca, Astellas, Pfizer and Opsona, and lecture fees from Novartis, Sanofi and Astellas. Dr M.J. Tunbridge has received travel sponsorship from Astellas. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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