Laboratory parameters and outcomes in hospitalized adults with COVID-19: a scoping review.

Autor: Zhu A; Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA. anz4001@med.cornell.edu., Zakusilo G; Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA.; Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, USA., Lee MS; Carle Illinois College of Medicine, Champaign, IL, USA., Kim J; Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA., Kim H; Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA.; Laboratory of Bacteriology, The Rockefeller University, New York, USA., Ying X; Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA., Chen YH; Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA., Jedlicka C; Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA., Mages K; Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA., Choi JJ; Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA.
Jazyk: angličtina
Zdroj: Infection [Infection] 2022 Feb; Vol. 50 (1), pp. 1-9. Date of Electronic Publication: 2021 Jul 10.
DOI: 10.1007/s15010-021-01659-w
Abstrakt: Background: Laboratory parameters and the associated clinical outcomes have been an area of focus in COVID-19 research globally.
Purpose: We performed a scoping review to synthesize laboratory values described in the literature and their associations with mortality and disease severity.
Methods: We identified all primary studies involving laboratory values with clinical outcomes as a primary endpoint by performing data searches in various systematic review databases until 10th August, 2020. Two reviewers independently reviewed all abstracts (13,568 articles) and full text (1126 articles) data. A total of 529 studies involving 165,020 patients from 28 different countries were included. Investigation of the number of studies and patients from a geographical perspective showed that the majority of published literature from January-March 2020 to April-June 2020 was from Asia, though there was a temporal shift in published studies to Europe and the Americas. For each laboratory value, the proportion of studies that noted a statistically significant (p < 0.05) correlation with adverse clinical outcomes (e.g., mortality, disease severity) was tabulated.
Results and Conclusion: Among frequently reported laboratory values, blood urea nitrogen was the most often reported predictor of mortality (91%); neutrophil-to-lymphocyte ratio was the most frequent statistically significant laboratory parameter in predicting disease severity (96%). This review highlights the temporal progression of laboratory value frequencies, as well as potentially distinct utilities of different markers for clinical outcomes of COVID-19. Future research pathways include using this collected data for focused quantitative meta-analyses of particular laboratory values correlated with clinical outcomes of mortality and disease severity.
(© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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