Responses of Clostridia to oxygen: from detoxification to adaptive strategies.

Autor: Morvan C; Laboratoire Pathogenèses des Bactéries Anaérobies, Institut Pasteur, Université de Paris, Paris, F-75015, France., Folgosa F; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, Oeiras, 2780-157, Portugal., Kint N; Laboratoire Pathogenèses des Bactéries Anaérobies, Institut Pasteur, Université de Paris, Paris, F-75015, France., Teixeira M; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, Oeiras, 2780-157, Portugal., Martin-Verstraete I; Laboratoire Pathogenèses des Bactéries Anaérobies, Institut Pasteur, Université de Paris, Paris, F-75015, France.; Institut Universitaire de France, Paris, France.
Jazyk: angličtina
Zdroj: Environmental microbiology [Environ Microbiol] 2021 Aug; Vol. 23 (8), pp. 4112-4125. Date of Electronic Publication: 2021 Jul 17.
DOI: 10.1111/1462-2920.15665
Abstrakt: Clostridia comprise bacteria of environmental, biotechnological and medical interest and many commensals of the gut microbiota. Because of their strictly anaerobic lifestyle, oxygen is a major stress for Clostridia. However, recent data showed that these bacteria can cope with O 2 better than expected for obligate anaerobes through their ability to scavenge, detoxify and consume O 2 . Upon O 2 exposure, Clostridia redirect their central metabolism onto pathways less O 2 -sensitive and induce the expression of genes encoding enzymes involved in O 2 -reduction and in the repair of oxidized damaged molecules. While Faecalibacterium prausnitzii efficiently consumes O 2 through a specific extracellular electron shuttling system requiring riboflavin, enzymes such as rubrerythrins and flavodiiron proteins with NAD(P)H-dependent O 2 - and/or H 2 O 2 -reductase activities are usually encoded in other Clostridia. These two classes of enzymes play indeed a pivotal role in O 2 tolerance in Clostridioides difficile and Clostridium acetobutylicum. Two main signalling pathways triggering O 2 -induced responses have been described so far in Clostridia. PerR acts as a key regulator of the O 2 - and/or reactive oxygen species-defence machinery while in C. difficile, σ B , the sigma factor of the general stress response also plays a crucial role in O 2 tolerance by controlling the expression of genes involved in O 2 scavenging and repair systems.
(© 2021 Society for Applied Microbiology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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