Factors associated with sleep disturbances in women undergoing treatment for early-stage breast cancer.

Autor: Grayson S; School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. Scw51@pitt.edu., Sereika S; School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA., Harpel C; School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.; Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Diego E; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Steiman JG; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., McAuliffe PF; School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA., Wesmiller S; School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Jazyk: angličtina
Zdroj: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2022 Jan; Vol. 30 (1), pp. 157-166. Date of Electronic Publication: 2021 Jul 10.
DOI: 10.1007/s00520-021-06373-9
Abstrakt: Purpose: The purpose of this study was to examine factors associated with sleep disturbance in women receiving adjuvant therapy for breast cancer.
Methods: This study employed a cross-sectional design using data collected at 3 months post-surgery from an ongoing longitudinal parent study. Participant data were divided into adjuvant treatment groups (chemotherapy, radiation, and aromatase inhibitors) and no adjuvant treatment groups. Symptoms were measured using patient self-report measures. Analysis of variance was used to assess between adjuvant treatment group differences in sleep disturbance. Regression analysis was performed to assess the relationship between sleep disturbance and other symptoms within adjuvant treatment groups.
Results: The sample included 156 women diagnosed with early-stage breast cancer. There were significant differences in levels of reported sleep disturbance between treatment groups (p = 0.049), with significantly higher levels of sleep disturbances in those receiving radiation compared to those receiving no adjuvant treatment (p = 0.038) and in those receiving chemotherapy and those receiving no adjuvant treatment (p = 0.027). Increased sleep disturbance was found to be a significant predictor for increased pain severity, nausea severity, anxiety, depressive symptoms, fatigue, decreased physical function, and decreased ability to participate in social roles and activities. Co-occurring symptoms with sleep disturbance differed between adjuvant treatment groups. Sleep disturbance was also associated with younger age (p = 0.008).
Conclusions: Patients undergoing chemotherapy or radiation for breast cancer report higher levels of sleep disturbance than those not receiving adjuvant therapy. Sleep disturbance is associated with other symptoms experienced by patients with cancer and thus requires continual assessment and future research into effective interventions.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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