Extra-uterine growth restriction in preterm infants: Neurodevelopmental outcomes according to different definitions.

Autor: De Rose DU; Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy; Neonatal Intensive Care Unit, Medical and Surgical Department of Fetus - Newborn - Infant, 'Bambino Gesù' Children's Hospital IRCCS, Rome, Italy. Electronic address: derosedomenicoumberto@gmail.com., Cota F; Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy; Università Cattolica Del Sacro Cuore, Rome, Italy., Gallini F; Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy; Università Cattolica Del Sacro Cuore, Rome, Italy., Bottoni A; Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy., Fabrizio GC; Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy., Ricci D; Pediatric Neurology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy; National Centre of Services and Research for the Prevention of Blindness and Rehabilitation of Low Vision Patients - IAPB Italia Onlus, Rome, Italy., Romeo DM; Università Cattolica Del Sacro Cuore, Rome, Italy; Pediatric Neurology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy., Mercuri E; Università Cattolica Del Sacro Cuore, Rome, Italy; Pediatric Neurology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy., Vento G; Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy; Università Cattolica Del Sacro Cuore, Rome, Italy., Maggio L; Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, Rome, Italy; Università Cattolica Del Sacro Cuore, Rome, Italy.
Jazyk: angličtina
Zdroj: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society [Eur J Paediatr Neurol] 2021 Jul; Vol. 33, pp. 135-145. Date of Electronic Publication: 2021 Jun 24.
DOI: 10.1016/j.ejpn.2021.06.004
Abstrakt: Aim: Extra-uterine Growth Restriction (EUGR) is common among preterm infants. Two types of EUGR definitions are still now available: cross-sectional definitions and longitudinal ones. In a cohort of very preterm infants, we aimed to evaluate which definition could better predict neurodevelopmental outcomes at 2 years of corrected age. We used Italian Neonatal Study Charts (INeS) growth charts and INTERGROWTH-21st (IG-21) standard charts and compared results.
Method: We restrospectively collected data from clinical charts of 324 preterm newborns with a gestational age ≤30 weeks born from 2012 to 2017. Then we compared forty-eight definitions (24 cross-sectional and 24 longitudinal) of EUGR, in term of neurodevelopmental outcomes at 2 years of corrected age.
Results: We included in the study 254 preterm infants, whose clinical information met the enrolment criteria. Nineteen out of 48 definitions of EUGR were significantly predictive both for Griffith's Development Quotient (GDQ) and Neurodevelopment Impairment (NDI). Among these, longitudinal definitions appeared to have a higher negative predictive value for NDI than cross-sectional ones. Furthermore, infants with EUGR appeared to have a lower cognitive score than their peers without EUGR.
Interpretation: A loss of Zs > 1 SDS in weight and head circumference, calculated from when physiological weight loss is over and identified as soon as possible rather than at discharge, better predicts neurodevelopmental outcomes of preterm infants.
Competing Interests: Declaration of competing interest None.
(Copyright © 2021 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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