Vitamin D deficiency and severity of pneumonia in Indonesian children.

Autor: Oktaria V; Faculty Medicine, Department of Paediatrics, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.; Faculty of Medicine, Department of Biostatistics, Epidemiology and Population Health, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.; Faculty of Medicine, Center for Child Health-Pediatric Research Office (CCH_PRO), Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Triasih R; Faculty of Medicine, Center for Child Health-Pediatric Research Office (CCH_PRO), Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.; Faculty of Medicine, Child Health Department, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia., Graham SM; Faculty Medicine, Department of Paediatrics, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia., Bines JE; Faculty Medicine, Department of Paediatrics, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia., Soenarto Y; Faculty of Medicine, Center for Child Health-Pediatric Research Office (CCH_PRO), Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.; Faculty of Medicine, Child Health Department, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia., Clarke MW; Faculty of Health, and Medical Sciences, Metabolomics Australia, Centre for Microscopy, Characterisation, and Analysis, and School of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia., Lauda M; Faculty of Medicine, Child Health Department, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia., Danchin M; Faculty Medicine, Department of Paediatrics, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Jul 09; Vol. 16 (7), pp. e0254488. Date of Electronic Publication: 2021 Jul 09 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0254488
Abstrakt: Objective: To determine the prevalence of vitamin D deficiency in Indonesian children hospitalized with pneumonia and evaluate the association between vitamin D status and severity of pneumonia.
Methods: A hospital-based cross-sectional study was conducted from February 2016 to July 2017 in two district hospitals in Yogyakarta province, Indonesia. Infants and young children aged 2-59 months hospitalized with pneumonia were recruited. Serum blood samples were collected on admission and analyzed for total serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 concentrations using liquid chromatography-tandem mass spectrometry. Vitamin D deficiency was defined as a level of serum vitamin D <50 nmol/L. The association between vitamin D deficiency and severity of hospitalized pneumonia according to WHO criteria, including the presence of danger signs, hypoxemia (SpO2 in air below 90%), duration of hospitalization, and admission to Intensive Care Unit (ICU), was analyzed using logistic regression.
Results: 133 children with WHO-defined pneumonia were enrolled in the study and 127 (96%) had their vitamin D status determined. The mean vitamin D concentration was 67 (± 24 SD) nmol/L and 19% of participants were vitamin D deficient. Age younger than 6 months was associated with prolonged hospitalization (> 5 days) and low birth weight and poor nutritional status on admission were risk factors for hypoxemia. However, vitamin D status was not associated with the presence of danger signs, duration of hospitalization, or hypoxemia.
Conclusions: One in every five children hospitalized with pneumonia was vitamin D deficient. Vitamin D status was not associated with the severity of pneumonia.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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