IgA and IgG reticulin antibodies in coeliac and non-coeliac patients.

Autor: Eade OE, Lloyd RS, Lang C, Wright R
Jazyk: angličtina
Zdroj: Gut [Gut] 1977 Dec; Vol. 18 (12), pp. 991-3.
DOI: 10.1136/gut.18.12.991
Abstrakt: Using indirect immunofluorescence, comparisons were made of patterns of staining of five tissue substrates with 28 RI reticulin antibody-positive coeliac sera, and 23 RI reticulin antibody-positive non-coeliac sera. IgA and IgG fluorescein conjugates were used separately. IgA antibodies were seen in 22 coeliac patients (78%) compared with three non-coeliacs (13%). Concomitant sinusoidal fluorescence (RS pattern) was seen more frequently with the non-coeliac (60.9%) than with the coeliac sera (10.7%). Such differences may help to distinguish those patients who should have a jejunal biopsy when using the reticulin antibody as a screening test for coeliac disease.
Databáze: MEDLINE