Amplicon residues in research laboratories masquerade as COVID-19 in surveillance tests.

Autor:	Davidi D; Department of Genetics, Harvard Medical School, Boston, MA, USA., Fitzgerald S; Harvard University Health Services, Harvard University, Cambridge, MA, USA., Glaspell HL; Biological Safety, Environment, Health and Safety, Cornell University, Ithaca, NY USA., Jalbert S; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Klapperich CM; Department of Biomedical Engineering and Precision Diagnostics Center, Boston University, Boston, MA 02215., Landaverde L; Department of Biomedical Engineering and Precision Diagnostics Center, Boston University, Boston, MA 02215., Maheras S; Harvard University Health Services, Harvard University, Cambridge, MA, USA., Mattoon SE; Biological Safety, Environment, Health and Safety, Cornell University, Ithaca, NY USA., Britto VM; Department of Medicine/University Health Services, Brown University, Providence, RI, USA., Nguyen GT; Harvard University Health Services, Harvard University, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Platt JT; Student Health Services, Boston University, Boston, MA, USA., Kuhfeldt K; Student Health Services, Boston University, Boston, MA, USA., Landsberg H; Student Health Services, Boston University, Boston, MA, USA., Stuopis CW; MIT Medical, Massachusetts Institute of Technology, Cambridge, MA, USA., Turse JE; Biological Safety, Environment, Health and Safety, Cornell University, Ithaca, NY USA., Hamer DH; Department of Global Health, Boston University School of Public Health, Boston, MA, USA.; Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; National Emerging Infectious Diseases Laboratory, Boston University, Boston, MA, USA., Springer M; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
Jazyk:	angličtina
Zdroj:	Cell reports methods [Cell Rep Methods] 2021 May 24; Vol. 1 (1), pp. 100005. Date of Electronic Publication: 2021 Apr 02.
DOI:	10.1016/j.crmeth.2021.100005
Abstrakt:	Asymptomatic surveillance testing together with COVID-19-related research can lead to positive SARS-CoV-2 tests resulting not from true infections, but non-infectious, non-hazardous by-products of research (amplicons). Amplicons can be widespread and persistent in lab environments and can be difficult to distinguish for true infections. We discuss prevention and mitigation strategies. (© 2021 The Authors.)
Databáze:	MEDLINE
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