| Autor: |
Cusack BJ; Clinical Pharmacology & Gerontology Research Unit, VA Medical Center, Boise, Idaho., Tesnohlidek DA, Loseke VL, Eggerth RM, Olson RD |
| Jazyk: |
angličtina |
| Zdroj: |
Research communications in chemical pathology and pharmacology [Res Commun Chem Pathol Pharmacol] 1987 Nov; Vol. 58 (2), pp. 269-72. |
| Abstrakt: |
Phenytoin pharmacokinetics were studied during continuous intravenous infusion in 12 New Zealand white rabbits. The mean clearance at 40 hours (5.1 +/- 1.1 ml/min per kg; mean +/- SE) was significantly greater than that at 16 hours (3.1 +/- 0.5 ml/min per kg; p less than 0.05). These data suggest that with chronic administration, autoinduction of metabolism results in an increase in the rate of phenytoin clearance in the rabbit. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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