Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women.

Autor: Adedokun B; Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA., Du Z; Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Gao G; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Ahearn TU; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Zirpoli G; Slone Epidemiology Center, Boston University, Boston, MA, USA., Figueroa J; Usher Institute and CRUK Edinburgh Centre, University of Edinburgh, Edinburgh, UK., John EM; Departments of Epidemiology & Population Health and of Medicine (Oncology) and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Bernstein L; Biomarkers of Early Detection and Prevention, Department of Population Sciences, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA., Hu JJ; Department of Public Health Sciences, University of Miami, Miami, FL, USA., Ziegler RG; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Nyante S; Department of Radiology, University of North Carolina, Chapel Hill, NC, USA., Bandera EV; Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., Ingles SA; Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Press MF; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Deming-Halverson SL; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA., Rodriguez-Gil JL; Genomics, Development and Disease Section, Genetic Disease Research Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA., Yao S; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Ogundiran TO; Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ojengbede O; Center for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria., Blot W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA., Troester MA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Nathanson KL; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hennis A; University of the West Indies, Bridgetown, Barbados.; Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA., Nemesure B; Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA., Ambs S; Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD, USA., Fiorica PN; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Sucheston-Campbell LE; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA., Bensen JT; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Kushi LH; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Torres-Mejia G; Center for Population Health Research, Instituto Nacional de Salud Publica, Cuernavaca, Mexico., Hu D; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Fejerman L; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Bolla MK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Michailidou K; Biostatistics Unit, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus., Pharoah PDP; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Wang Q; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Sandler DP; Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA., Taylor JA; Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA., O'Brien KM; Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA., Kitahara CM; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Falusi AG; Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria., Babalola C; Department of Pharmaceutical Chemistry, University of Ibadan, Ibadan, Oyo, Nigeria., Yarney J; Korle Bu Teaching Hospital, Accra, Ghana., Awuah B; Komfo Anokye Teaching Hospital, Kumasi, Ghana., Addai-Wiafe B; Peace and Love Hospital, Kumasi, Ghana., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Olshan AF; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Ambrosone CB; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Conti DV; Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Ziv E; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Olopade OI; Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA., Garcia-Closas M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Palmer JR; Slone Epidemiology Center, Boston University, Boston, MA, USA., Haiman CA; Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. haiman@usc.edu., Huo D; Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA. dhuo@health.bsd.uchicago.edu.; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. dhuo@health.bsd.uchicago.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 Jul 07; Vol. 12 (1), pp. 4198. Date of Electronic Publication: 2021 Jul 07.
DOI: 10.1038/s41467-021-24327-x
Abstrakt: Our study describes breast cancer risk loci using a cross-ancestry GWAS approach. We first identify variants that are associated with breast cancer at P < 0.05 from African ancestry GWAS meta-analysis (9241 cases and 10193 controls), then meta-analyze with European ancestry GWAS data (122977 cases and 105974 controls) from the Breast Cancer Association Consortium. The approach identifies four loci for overall breast cancer risk [1p13.3, 5q31.1, 15q24 (two independent signals), and 15q26.3] and two loci for estrogen receptor-negative disease (1q41 and 7q11.23) at genome-wide significance. Four of the index single nucleotide polymorphisms (SNPs) lie within introns of genes (KCNK2, C5orf56, SCAMP2, and SIN3A) and the other index SNPs are located close to GSTM4, AMPD2, CASTOR2, and RP11-168G16.2. Here we present risk loci with consistent direction of associations in African and European descendants. The study suggests that replication across multiple ancestry populations can help improve the understanding of breast cancer genetics and identify causal variants.
Databáze: MEDLINE