Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study.

Autor: Tura A; CNR Institute of Neuroscience, Padova, Italy andrea.tura@cnr.it., Grespan E; CNR Institute of Neuroscience, Padova, Italy., Göbl CS; Division of Obstetrics and Feto-Maternal Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria., Koivula RW; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, U.K.; Genetic and Molecular Epidemiology, Department of Clinical Science, Lund University, Skåne University Hospital Malmö, Malmö, Sweden., Franks PW; Genetic and Molecular Epidemiology, Department of Clinical Science, Lund University, Skåne University Hospital Malmö, Malmö, Sweden., Pearson ER; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, U.K., Walker M; Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, U.K., Forgie IM; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, U.K., Giordano GN; Genetic and Molecular Epidemiology, Department of Clinical Science, Lund University, Skåne University Hospital Malmö, Malmö, Sweden., Pavo I; Eli Lilly Regional Operations Ges.m.b.H., Vienna, Austria., Ruetten H; CardioMetabolism & Respiratory Medicine, Boehringer Ingelheim International GmbH, Ingelheim/Rhein, Germany., Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., McCarthy MI; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, U.K.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, U.K., Pedersen O; Section of Metabolic Genetics, Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark., Schwenk JM; Affinity Proteomics, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden., Adamski J; Institute of Experimental Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., De Masi F; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Disease Systems Biology Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tsirigos KD; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Disease Systems Biology Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brunak S; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; Disease Systems Biology Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Viñuela A; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, U.K., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, U.K., McDonald TJ; Blood Sciences, Royal Devon and Exeter NHS Foundation Trust, Exeter, U.K., Kokkola T; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Vangipurapu J; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Cederberg H; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Laakso M; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Rutters F; Department of Epidemiology and Data Science, Amsterdam Medical Centre, location VUMC, Amsterdam, the Netherlands., Elders PJM; Department of Epidemiology and Data Science, Amsterdam Medical Centre, location VUMC, Amsterdam, the Netherlands., Koopman ADM; Department of Epidemiology and Data Science, Amsterdam Medical Centre, location VUMC, Amsterdam, the Netherlands., Beulens JW; Department of Epidemiology and Data Science, Amsterdam Medical Centre, location VUMC, Amsterdam, the Netherlands., Ridderstråle M; Department of Clinical Sciences, Diabetes & Endocrinology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden., Hansen TH; Section of Metabolic Genetics, Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark., Allin KH; Section of Metabolic Genetics, Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark., Hansen T; Section of Metabolic Genetics, Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark., Vestergaard H; Section of Metabolic Genetics, Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Bornholms Hospital, Rønne, Denmark., Mari A
Jazyk: angličtina
Zdroj: Diabetes [Diabetes] 2021 Sep; Vol. 70 (9), pp. 2092-2106. Date of Electronic Publication: 2021 Jul 07.
DOI: 10.2337/db21-0227
Abstrakt: Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants ( N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA 1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA 1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control subjects. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, those with IGT showed lower insulin sensitivity, insulin secretion at reference glucose (ISR r ), and insulin secretion potentiation ( P < 0.002). Conversely, those with IA1c showed higher insulin sensitivity and ISR r ( P < 0.0001). Among groups with two defects, we similarly found differences in both BCF and insulin sensitivity. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, P < 0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared with the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.
(© 2021 by the American Diabetes Association.)
Databáze: MEDLINE
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