Cytogenetic follow-up studies on humans with internal and external exposure to ionizing radiation.

Autor:	Balajee AS; Cytogenetic Biodosimetry Laboratory, Radiation Emergency Assistance Centre/Training Site, Oak Ridge Institute for Science and Education, Oak Ridge Associated Universities, Oak Ridge, TN, United States of America., Livingston GK; Cytogenetic Biodosimetry Laboratory, Radiation Emergency Assistance Centre/Training Site, Oak Ridge Institute for Science and Education, Oak Ridge Associated Universities, Oak Ridge, TN, United States of America., Escalona MB; Cytogenetic Biodosimetry Laboratory, Radiation Emergency Assistance Centre/Training Site, Oak Ridge Institute for Science and Education, Oak Ridge Associated Universities, Oak Ridge, TN, United States of America., Ryan TL; Cytogenetic Biodosimetry Laboratory, Radiation Emergency Assistance Centre/Training Site, Oak Ridge Institute for Science and Education, Oak Ridge Associated Universities, Oak Ridge, TN, United States of America., Goans RE; Cytogenetic Biodosimetry Laboratory, Radiation Emergency Assistance Centre/Training Site, Oak Ridge Institute for Science and Education, Oak Ridge Associated Universities, Oak Ridge, TN, United States of America., Iddins CJ; Cytogenetic Biodosimetry Laboratory, Radiation Emergency Assistance Centre/Training Site, Oak Ridge Institute for Science and Education, Oak Ridge Associated Universities, Oak Ridge, TN, United States of America.
Jazyk:	angličtina
Zdroj:	Journal of radiological protection : official journal of the Society for Radiological Protection [J Radiol Prot] 2021 Nov 15; Vol. 41 (4). Date of Electronic Publication: 2021 Nov 15.
DOI:	10.1088/1361-6498/ac125a
Abstrakt:	Cells exposed to ionizing radiation have a wide spectrum of DNA lesions that include DNA single-strand breaks, DNA double-strand breaks (DSBs), oxidative base damage and DNA-protein crosslinks. Among them, DSB is the most critical lesion, which when mis-repaired leads to unstable and stable chromosome aberrations. Currently, chromosome aberration analysis is the preferred method for biological monitoring of radiation-exposed humans. Stable chromosome aberrations, such as inversions and balanced translocations, persist in the peripheral blood lymphocytes of radiation-exposed humans for several years and, therefore, are potentially useful tools to prognosticate the health risks of radiation exposure, particularly in the hematopoietic system. In this review, we summarize the cytogenetic follow-up studies performed by REAC/TS (Radiation Emergency Assistance Center/Training site, Oak Ridge, USA) on humans exposed to internal and external radiation. In the light of our observations as well as the data existing in the literature, this review attempts to highlight the importance of follow-up studies for predicting the extent of genomic instability and its impact on delayed health risks in radiation-exposed victims. (© 2021 Society for Radiological Protection. Published on behalf of SRP by IOP Publishing Limited. All rights reserved.)
Databáze:	MEDLINE
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