Azole-resistant Aspergillus fumigatus is highly prevalent in the environment of Vietnam, with marked variability by land use type.

Autor: Duong TN; Faculty of Medicine and Health, The University of Sydney, Sydney, 2145, Australia.; Oxford University Clinical Research Unit, Ho Chi Minh City, 70000, Vietnam., Le TV; Oxford University Clinical Research Unit, Ho Chi Minh City, 70000, Vietnam., Tran KH; Oxford University Clinical Research Unit, Ho Chi Minh City, 70000, Vietnam., Nguyen PT; Oxford University Clinical Research Unit, Ho Chi Minh City, 70000, Vietnam., Nguyen BT; Woolcock Institute of Medical Research, Hanoi, 10000, Vietnam., Nguyen TA; Woolcock Institute of Medical Research, Hanoi, 10000, Vietnam., Nguyen HP; Hospital for Tropical Diseases, Ho Chi Minh, 70000, Vietnam., Nguyen BT; National Lung Hospital, Hanoi, 10000, Vietnam.; Hanoi Medical University, Hanoi, 10000, Vietnam., Fisher MC; MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1NY, UK., Rhodes J; MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, W2 1NY, UK., Marks G; Woolcock Institute of Medical Research, Hanoi, 10000, Vietnam., Fox GJ; Faculty of Medicine and Health, The University of Sydney, Sydney, 2145, Australia.; Woolcock Institute of Medical Research, Hanoi, 10000, Vietnam., Chen SC; Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, 2145, Australia.; Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital, Sydney, 2145, Australia., Walsh MG; Faculty of Medicine and Health, The University of Sydney, Sydney, 2145, Australia.; Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, 2145, Australia., Barrs VR; Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, 2145, Australia.; Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong., Talbot J; Faculty of Veterinary Science, The University of Sydney, Sydney, 2145, Australia., Halliday CL; Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, 2145, Australia.; Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital, Sydney, 2145, Australia., Sorrell TC; Faculty of Medicine and Health, The University of Sydney, Sydney, 2145, Australia.; Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, 2145, Australia.; Westmead Institute for Medical Research, Westmead, Sydney, 2145, Australia., Day JN; Oxford University Clinical Research Unit, Ho Chi Minh City, 70000, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK., Beardsley J; Faculty of Medicine and Health, The University of Sydney, Sydney, 2145, Australia.; Oxford University Clinical Research Unit, Ho Chi Minh City, 70000, Vietnam.; Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, 2145, Australia.; Westmead Institute for Medical Research, Westmead, Sydney, 2145, Australia.
Jazyk: angličtina
Zdroj: Environmental microbiology [Environ Microbiol] 2021 Dec; Vol. 23 (12), pp. 7632-7642. Date of Electronic Publication: 2021 Jul 16.
DOI: 10.1111/1462-2920.15660
Abstrakt: Azole-resistant environmental Aspergillus fumigatus presents a threat to public health but the extent of this threat in Southeast Asia is poorly described. We conducted environmental surveillance in the Mekong Delta region of Vietnam, collecting air and ground samples across key land-use types, and determined antifungal susceptibilities of Aspergillus section Fumigati (ASF) isolates and azole concentrations in soils. Of 119 ASF isolates, 55% were resistant (or non-wild type) to itraconazole, 65% to posaconazole and 50% to voriconazole. Azole resistance was more frequent in A. fumigatus sensu stricto isolates (95%) than other ASF species (32%). Resistant isolates and agricultural azole residues were overrepresented in samples from cultivated land. cyp51A gene sequence analysis showed 38/56 resistant A. fumigatus sensu stricto isolates carried known resistance mutations, with TR 34 /L98H most frequent (34/38).
(© 2021 Society for Applied Microbiology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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