Information capacity and robustness of encoding in the medial prefrontal cortex are modulated by the bioavailability of serotonin and the time elapsed from the cue during a reward-driven task.

Autor: Pereyra AE; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina. apereyra@dna.uba.ar., Mininni CJ; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Zanutto BS; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina.; Universidad de Buenos Aires, Facultad de Ingeniería, Instituto de Ingeniería Biomédica, Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Jul 06; Vol. 11 (1), pp. 13882. Date of Electronic Publication: 2021 Jul 06.
DOI: 10.1038/s41598-021-93313-6
Abstrakt: Serotonin (5-HT) is a key neuromodulator of medial prefrontal cortex (mPFC) functions. Pharmacological manipulation of systemic 5-HT bioavailability alters the electrical activity of mPFC neurons. However, 5-HT modulation at the population level is not well characterized. In the present study, we made single neuron extracellular recordings in the mPFC of rats performing an operant conditioning task, and analyzed the effect of systemic administration of fluoxetine (a selective serotonin reuptake inhibitor) on the information encoded in the firing activity of the neural population. Chronic (longer than 15 days), but not acute (less than 15 days), fluoxetine administration reduced the firing rate of mPFC neurons. Moreover, fluoxetine treatment enhanced pairwise entropy but diminished noise correlation and redundancy in the information encoded, thus showing how mPFC differentially encodes information as a function of 5-HT bioavailability. Information about the occurrence of the reward-predictive stimulus was maximized during reward consumption, around 3 to 4 s after the presentation of the cue, and it was higher under chronic fluoxetine treatment. However, the encoded information was less robust to noise corruption when compared to control conditions.
Databáze: MEDLINE
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