Cumulative exposure to psychosocial stressors at work and global cognitive function: the PROspective Quebec Study on Work and Health.

Autor:	Duchaine CS; Population Health and Optimal Health Practices Unit, CHU de Québec-Laval University Research Center, Québec, Québec, Canada.; Social and Preventive Medicine, Laval University, Faculty of Medicine, Québec, Québec, Canada.; Centre d'excellence sur le vieillissement de Québec, Québec, Québec, Canada.; VITAM, Centre de recherche en santé durable, Québec, Québec, Canada.; Institut sur le vieillissement et la participation sociale des aînés, Université Laval, Québec, Québec, Canada., Brisson C; Population Health and Optimal Health Practices Unit, CHU de Québec-Laval University Research Center, Québec, Québec, Canada.; Social and Preventive Medicine, Laval University, Faculty of Medicine, Québec, Québec, Canada.; Centre d'excellence sur le vieillissement de Québec, Québec, Québec, Canada.; VITAM, Centre de recherche en santé durable, Québec, Québec, Canada.; Institut sur le vieillissement et la participation sociale des aînés, Université Laval, Québec, Québec, Canada., Talbot D; Population Health and Optimal Health Practices Unit, CHU de Québec-Laval University Research Center, Québec, Québec, Canada.; Social and Preventive Medicine, Laval University, Faculty of Medicine, Québec, Québec, Canada., Gilbert-Ouimet M; Population Health and Optimal Health Practices Unit, CHU de Québec-Laval University Research Center, Québec, Québec, Canada.; Health Sciences, Université du Québec à Rimouski Campus de Lévis, Lévis, Québec, Canada., Trudel X; Population Health and Optimal Health Practices Unit, CHU de Québec-Laval University Research Center, Québec, Québec, Canada.; Social and Preventive Medicine, Laval University, Faculty of Medicine, Québec, Québec, Canada.; Centre d'excellence sur le vieillissement de Québec, Québec, Québec, Canada.; VITAM, Centre de recherche en santé durable, Québec, Québec, Canada., Vézina M; Institut national de santé publique du Québec, Québec, Québec, Canada., Milot A; Population Health and Optimal Health Practices Unit, CHU de Québec-Laval University Research Center, Québec, Québec, Canada.; Medicine, Laval University, Faculty of medicine, Québec, Québec, Canada., Diorio C; Social and Preventive Medicine, Laval University, Faculty of Medicine, Québec, Québec, Canada.; Oncology, CHU de Québec-Université Laval Research Center, Québec, Québec, Canada., Ndjaboué R; Social and Preventive Medicine, Laval University, Faculty of Medicine, Québec, Québec, Canada.; VITAM, Centre de recherche en santé durable, Québec, Québec, Canada., Giguère Y; Population Health and Optimal Health Practices Unit, CHU de Québec-Laval University Research Center, Québec, Québec, Canada.; Medicine, Laval University, Faculty of medicine, Québec, Québec, Canada., Mâsse B; Médecine sociale et préventive, Université de Montréal, Montréal, Québec, Canada., Dionne CE; Population Health and Optimal Health Practices Unit, CHU de Québec-Laval University Research Center, Québec, Québec, Canada.; Social and Preventive Medicine, Laval University, Faculty of Medicine, Québec, Québec, Canada.; Centre d'excellence sur le vieillissement de Québec, Québec, Québec, Canada.; VITAM, Centre de recherche en santé durable, Québec, Québec, Canada.; Institut sur le vieillissement et la participation sociale des aînés, Université Laval, Québec, Québec, Canada., Maunsell E; Population Health and Optimal Health Practices Unit, CHU de Québec-Laval University Research Center, Québec, Québec, Canada.; Social and Preventive Medicine, Laval University, Faculty of Medicine, Québec, Québec, Canada., Laurin D; Population Health and Optimal Health Practices Unit, CHU de Québec-Laval University Research Center, Québec, Québec, Canada danielle.laurin@pha.ulaval.ca.; Centre d'excellence sur le vieillissement de Québec, Québec, Québec, Canada.; VITAM, Centre de recherche en santé durable, Québec, Québec, Canada.; Institut sur le vieillissement et la participation sociale des aînés, Université Laval, Québec, Québec, Canada.; Pharmacy, Laval University, Faculty of Pharmacy, Quebec, Quebec, Canada.
Jazyk:	angličtina
Zdroj:	Occupational and environmental medicine [Occup Environ Med] 2021 Dec; Vol. 78 (12), pp. 884-892. Date of Electronic Publication: 2021 Jul 06.
DOI:	10.1136/oemed-2021-107407
Abstrakt:	Objectives: Psychosocial stressors at work have been proposed as modifiable risk factors for mild cognitive impairment (MCI). This study aimed to evaluate the effect of cumulative exposure to psychosocial stressors at work on cognitive function. Methods: This study was conducted among 9188 white-collar workers recruited in 1991-1993 (T1), with follow-ups 8 (T2) and 24 years later (T3). After excluding death, losses to follow-up and retirees at T2, 5728 participants were included. Psychosocial stressors at work were measured according to the Karasek's questionnaire. Global cognitive function was measured with the Montreal Cognitive Assessment. Cumulative exposures to low psychological demand, low job control, passive job and high strain job were evaluated using marginal structural models including multiple imputation and inverse probability of censoring weighting. Results: In men, cumulative exposures (T1 and T2) to low psychological demand, low job control or passive job were associated with higher prevalences of more severe presentation of MCI (MSMCI) at T3 (Prevalence ratios (PRs) and 95% CIs of 1.50 (1.16 to 1.94); 1.38 (1.07 to 1.79) and 1.55 (1.20 to 2.00), respectively), but not with milder presentation of MCI. In women, only exposure to low psychological demand or passive job at T2 was associated with higher prevalences of MSMCI at T3 (PRs and 95% CI of 1.39 (0.97 to 1.99) and 1.29 (0.94 to 1.76), respectively). Conclusions: These results support the deleterious effect of a low stimulating job on cognitive function and the cognitive reserve theory. Psychosocial stressors at work could be part of the effort for the primary prevention of cognitive decline. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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