Persistent CO 2 reactivity deficits are associated with neurological dysfunction up to one year after repetitive mild closed head injury in adolescent mice.

Autor: Wu L; Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Chan ST; Department of Radiology, A. Martino's Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA., Edmiston WJ 3rd; Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jin G; Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Levy ES; Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kwong KK; Department of Radiology, A. Martino's Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA., Mannix R; Department of Emergency Medicine, Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA., Meehan WP; Department of Emergency Medicine, Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Department of Orthopedics, Division of Sports Medicine, Boston, MA, USA., Chifamba FF; Department of Neurology, Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA., Lipton JO; Department of Neurology, Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Whalen MJ; Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Chen YI; Department of Radiology, A. Martino's Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Jazyk: angličtina
Zdroj: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2021 Dec; Vol. 41 (12), pp. 3260-3272. Date of Electronic Publication: 2021 Jul 06.
DOI: 10.1177/0271678X211021771
Abstrakt: Cerebrovascular reactivity (CVR) deficits in adolescents with concussion may persist after resolution of neurological symptoms. Whether or not CVR deficits predict long term neurological function is unknown. We used adolescent mice closed head injury (CHI) models (54 g, 107 cm or 117 cm drop height), followed by blood oxygenation level dependent (BOLD)-functional MRI with CO 2 challenge to assess CVR and brain connectivity. At one week, 3HD 107 cm mice showed delayed BOLD responses (p = 0.0074), normal striatal connectivity , and an impaired respiratory rate response to CO 2 challenge (p = 0.0061 in ΔRmax). The 107 cm group developed rotarod deficits at 6 months (p = 0.02) and altered post-CO 2 brain connectivity (3-fold increase in striatum to motor cortex correlation coefficient) by one year, but resolved their CVR and respiratory rate impairments, and did not develop cognitive or circadian activity deficits. In contrast, the 117 cm group had persistent CVR (delay time: p = 0.016; washout time: p = 0.039) and circadian activity deficits (free-running period: 23.7 hr in sham vs 23.9 hr in 3HD; amplitude: 0.15 in sham vs 0.2 in 3HD; peak activity: 18 in sham vs 21 in 3HD) at one year. Persistent CVR deficits after concussion may portend long-term neurological dysfunction. Further studies are warranted to determine the utility of CVR to predict chronic neurological outcome after mild traumatic brain injury.
Databáze: MEDLINE