Antimicrobial and antioxidant activities of secondary metabolites from endophytic fungus Botryosphaeria fabicerciana (MGN23-3) associated to Morus nigra L.

Autor:	Silva AAD; Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Paraná, Brazil., Polonio JC; Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Paraná, Brazil., Bulla AM; Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Paraná, Brazil., Polli AD; Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Paraná, Brazil., Castro JC; Post-Graduate Program in Food Science, State University of Maringa, Maringa, Paraná, Brazil., Soares LC; Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Paraná, Brazil., Oliveira-Junior VA; Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Paraná, Brazil., Vicentini VEP; Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Paraná, Brazil., Oliveira AJB; Post-Graduate Program in Pharmaceutical Sciences, State University of Maringa, Maringa, Paraná, Brazil., Gonçalves JE; Program of Master in Health Promotion and Program of Master in Clean Technologies, University Center of Maringa, Maringa, Paraná, Brazil., Gonçalves RAC; Post-Graduate Program in Pharmaceutical Sciences, State University of Maringa, Maringa, Paraná, Brazil., Azevedo JL; Department of Genetics - Escola Superior de Agricultura Luiz de Queiroz - ESALQ/USP, Piracicaba, São Paulo, Brazil., Abreu-Filho BA; Department of Basic Health Sciences, State University of Maringa, Maringa, Paraná, Brazil., Pamphile JA; Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Paraná, Brazil.
Jazyk:	angličtina
Zdroj:	Natural product research [Nat Prod Res] 2022 Jun; Vol. 36 (12), pp. 3158-3162. Date of Electronic Publication: 2021 Jul 06.
DOI:	10.1080/14786419.2021.1947272
Abstrakt:	This study was to evaluate the biological activity of the extract of Botryosphaeria fabicerciana isolated from leaves of Morus nigra . The volatile compounds from the crude extract were analysed by GC-MS which demonstrate that mellein and β-orcinaldehyde were are the major compounds. The best minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extract was observed against Gram-positive bacteria, with a MIC of 15.6 μg/mL towards B. cereus and MIC of 62.5 μg/mL towards S. aureus and B. subtilis . MBC values of 31.25 μg/mL, 62.5 μg/mL, and 250 μg/mL were observed towards B. cereus , B. subtilis , and S. aureus , respectively. The cytotoxicity analyses showed CC 50 of 115 μg/mL. The crude extract showed antioxidant activity by the DPPH, ABTS, and FRAP assays. Therefore, the extract of the endophytic fungus presented biotechnological potential as an antibacterial and antioxidant agent.
Databáze:	MEDLINE
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