Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID-19.

Autor: Brasil S; Universidade de São Paulo Brazil., Renck AC; Universidade de São Paulo Brazil., Taccone FS; Universitè Libre de Bruxelles Belgium., Fontoura Solla DJ; Universidade de São Paulo Brazil., Tomazini BM; Universidade de São Paulo Brazil., Wayhs SY; Universidade de São Paulo Brazil., Fonseca S; Universidade de São Paulo Brazil., Bassi E; Universidade de São Paulo Brazil., Lucena B; Universidade de São Paulo Brazil., De Carvalho Nogueira R; Universidade de São Paulo Brazil., Paiva W; Universidade de São Paulo Brazil., Teixeira MJ; Universidade de São Paulo Brazil., Frade Costa EM; Universidade de São Paulo Brazil., Sá Malbouisson LM; Universidade de São Paulo Brazil.
Jazyk: angličtina
Zdroj: Obesity science & practice [Obes Sci Pract] 2021 May 27; Vol. 7 (6), pp. 751-759. Date of Electronic Publication: 2021 May 27 (Print Publication: 2021).
DOI: 10.1002/osp4.534
Abstrakt: Objective: Multiple factors have been identified as causes of intracranial compliance impairment (ICCI) among patients with obesity. On the other hand, obesity has been linked with worst outcomes in COVID-19. Thus, the hypothesis of severe acute respiratory syndrome (SARS) conducing to cerebral hemodynamic disorders (CHD) able to worsen ICCI and play an additional role on prognosis determination for COVID-19 among obese patients becomes suitable.
Methods: 50 cases of SARS by COVID-19 were evaluated, for the presence of ICCI and cerebrovascular circulatory disturbances in correspondence with whether unfavorable outcomes (death or impossibility for mechanical ventilation weaning [MVW]) within 7 days after evaluation. The objective was to observe whether obese patients (BMI ≥ 30) disclosed worse outcomes and tests results compared with lean subjects with same clinical background.
Results: 23 (46%) patients among 50 had obesity. ICCI was verified in 18 (78%) obese, whereas in 13 (48%) of 27 non-obese ( p  = 0,029). CHD were not significantly different between groups, despite being high prevalent in both. 69% unfavorable outcomes were observed among obese and 44% for lean subjects ( p  = 0,075).
Conclusion: In the present study, intracranial compliance impairment was significantly more observed among obese subjects and may have contributed for SARS COVID-19 worsen prognosis.
Competing Interests: There is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.
(© 2021 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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