Tailoring chemical compositions of biodegradable mesoporous organosilica nanoparticles for controlled slow release of chemotherapeutic drug.

Autor: Mai NXD; Center for Innovative Materials and Architectures, Ho Chi Minh City, Viet Nam; Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Faculty of Physics and Engineering Physics, University of Science, Ho Chi Minh City, Viet Nam., Nguyen TT; Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Viet Nam; School of Biomedical Engineering, International University, Ho Chi Minh City, Viet Nam., Vong LB; Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Viet Nam; School of Biomedical Engineering, International University, Ho Chi Minh City, Viet Nam., Dang MD; Center for Innovative Materials and Architectures, Ho Chi Minh City, Viet Nam; Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Viet Nam., Nguyen TTT; Center for Innovative Materials and Architectures, Ho Chi Minh City, Viet Nam; Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Viet Nam., Nguyen LHT; Center for Innovative Materials and Architectures, Ho Chi Minh City, Viet Nam; Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Viet Nam., Ta HKT; Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Faculty of Materials Science and Technology, University of Science, Ho Chi Minh City, Viet Nam., Nguyen TH; Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Viet Nam; School of Biomedical Engineering, International University, Ho Chi Minh City, Viet Nam., Phan TB; Center for Innovative Materials and Architectures, Ho Chi Minh City, Viet Nam; Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Viet Nam. Electronic address: pbthang@inomar.edu.vn., Doan TLH; Center for Innovative Materials and Architectures, Ho Chi Minh City, Viet Nam; Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Viet Nam. Electronic address: dlhtan@inomar.edu.vn.
Jazyk: angličtina
Zdroj: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2021 Aug; Vol. 127, pp. 112232. Date of Electronic Publication: 2021 Jun 04.
DOI: 10.1016/j.msec.2021.112232
Abstrakt: Biodegradable periodic mesoporous organosilica nanoparticles (B-PMO) are an outstanding nanocarrier due to their biodegradability and high drug load capacities. The present study describes a synthesis of a phenylene-containing tetrasulfide based B-PMO, named P4S. The incorporation of aromatic phenylene groups into the framework creates a strong interaction between nanoparticles (NPs) with aromatic rings in the cordycepin molecules. This results in the low release profile under various conditions. In addition, the replacement of this linker slowed the degradation of nanoparticles. The physicochemical properties of the nanoparticles are evaluated and compared with a biodegradable ethane-containing tetrasulfide based PMO and a non-degradable MCM-41. The biodegradability of P4S is also demonstrated in a reducing environment and the 100 nm spherical nanoparticles completely decomposed within 14 days. The porous structure of P4S has a high loading of hydrophilic cordycepin (approximately 731.52 mg g -1 ) with a slow releasing speed. The release rates of P4S NPs are significantly lower than other materials, such as liposomes, gelatin nanoparticles, and photo-crosslinked hyaluronic acid methacrylate hydrogels, in the same solution. This specific release behavior could guarantee drug therapeutic effects with minimum side-effects and optimized drug dosages. Most importantly, according to the in vitro cytotoxicity study, cordycepin-loaded P4S NPs could retain the toxicity against liver cancer cell (HepG2) while suppressed the cytotoxicity against normal cells (BAEC).
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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