Establishing a controlled hookworm human infection (CHHI) model for Africa: A report from the stakeholders meeting held in Lambaréné, Gabon, November 10-11, 2019.

Autor: Alabi A; Centre de Recherches Médicales de Lambaréné, BP242, Lambaréné, Gabon. a.alabi@lumc.nl.; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands. a.alabi@lumc.nl., Hussain M; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands., Hoogerwerf MA; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands.; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Mengome CN; Centre de Recherches Médicales de Lambaréné, BP242, Lambaréné, Gabon., Egesa M; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, P.O. Box 49, Entebbe, Uganda.; Uganda Virus Research Institute, P.O. Box 49, Entebbe, Uganda., Driciru E; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, P.O. Box 49, Entebbe, Uganda., Wammes LJ; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Kruize YCM; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands., Sartono E; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands., Adegnika AA; Centre de Recherches Médicales de Lambaréné, BP242, Lambaréné, Gabon.; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.; German Center for Infection Research (DZIF), Tübingen, Germany.; Fondation pour la Recherche Scientifique, 72 BP45, Cotonou, Bénin., Kremsner PG; Centre de Recherches Médicales de Lambaréné, BP242, Lambaréné, Gabon.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.; German Center for Infection Research (DZIF), Tübingen, Germany., Yazdanbakhsh M; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands., Agnandji ST; Centre de Recherches Médicales de Lambaréné, BP242, Lambaréné, Gabon.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
Jazyk: angličtina
Zdroj: Archives of public health = Archives belges de sante publique [Arch Public Health] 2021 Jul 05; Vol. 79 (1), pp. 120. Date of Electronic Publication: 2021 Jul 05.
DOI: 10.1186/s13690-021-00650-z
Abstrakt: Background: Hookworm is a major contributor to worldwide disease burden with over 230 million people infected. It has been identified as one of the Neglected Tropical Diseases that can be controlled and even eliminated through mass drug administration and other effective interventions. Mathematical models have shown that hookworm can only be eliminated via a vaccine. Controlled Hookworm Human Infection (CHHI) models can facilitate rapid development of vaccines and drugs.
Methods: As a first step towards the establishment of CHHI in Africa, we held a stakeholders meeting in Lamberene, Gabon from 10 to 11 November 2019.
Results: Discussions revolved around the roles of the different regulatory institutions concerned; the need to strengthen existing regulatory capacity and the role of legislation; creating Gabon-specific ethical guidelines to govern Controlled Human Infection (CHI) studies; development of a study protocol; consideration of cultural and social peculiarities; the need for regular joint review meetings between interested parties throughout the process of protocol implementation; and participant compensation. Moreover, operational considerations concerning the introduction of CHHI in Gabon include the use of the local strain of hookworm for the challenge infections, capacity building for the local production of challenge material, and the establishment of adequate quality assurance procedures.
Conclusion: The workshop addressed several of the anticipated hurdles to the successful implementation of CHHI in Gabon. It is our aim that this report will stimulate interest in the implementation of this model in the sub-Saharan African setting.
Databáze: MEDLINE
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