Smartphone-based optical palpation: towards elastography of skin for telehealth applications.

Autor:	Sanderson RW; BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009, Australia.; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Crawley 6009, Australia., Fang Q; BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009, Australia.; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Crawley 6009, Australia., Curatolo A; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Crawley 6009, Australia.; Currently with International Centre for Translational Eye Research, Skierniewicka 10A, 01-230 Warsaw, Poland and Institute of Physical Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/52, 01-224 Warsaw, Poland., Taba A; BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009, Australia.; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Crawley 6009, Australia., DeJong HM; BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009, Australia.; Perth Scar and Pain Clinic, Mt Pleasant, Western Australia 6160, Australia.; Fiona Wood Foundation, Fiona Stanley Hospital, Murdoch, Western Australia 6150, Australia., Wood FM; Fiona Wood Foundation, Fiona Stanley Hospital, Murdoch, Western Australia 6150, Australia.; Burn Injury Research Unit, The University of Western Australia, Crawley, Western Australia 6009, Australia.; Burn Service of Western Australia, Fiona Stanley Hospital, Murdoch, Western Australia 6150, Australia., Kennedy BF; BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009, Australia.; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Crawley 6009, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Australia.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2021 May 06; Vol. 12 (6), pp. 3117-3132. Date of Electronic Publication: 2021 May 06 (Print Publication: 2021).
DOI:	10.1364/BOE.424567
Abstrakt:	Smartphones are now integral to many telehealth services that provide remote patients with an improved diagnostic standard of care. The ongoing management of burn wounds and scars is one area in which telehealth has been adopted, using video and photography to assess the repair process over time. However, a current limitation is the inability to evaluate scar stiffness objectively and repeatedly: an essential measurement for classifying the degree of inflammation and fibrosis. Optical elastography detects mechanical contrast on a micrometer- to millimeter-scale, however, typically requires expensive optics and bulky imaging systems, making it prohibitive for wide-spread adoption in telehealth. More recently, a new variant of optical elastography, camera-based optical palpation, has demonstrated the capability to perform elastography at low cost using a standard digital camera. In this paper, we propose smartphone-based optical palpation, adapting camera-based optical palpation by utilizing a commercially available smartphone camera to provide sub-millimeter resolution imaging of mechanical contrast in scar tissue in a form factor that is amenable to telehealth. We first validate this technique on a silicone phantom containing a 5 × 5 × 1 mm 3 embedded inclusion, demonstrating comparative image quality between mounted and handheld implementations. We then demonstrate preliminary in vivo smartphone-based optical palpation by imaging a region of healthy skin and two scars on a burns patient, showing clear mechanical contrast between regions of scar tissue and healthy tissue. This study represents the first implementation of elastography on a smartphone device, extending the potential application of elastography to telehealth. Competing Interests: B.F.K. and A.C. hold shares in OncoRes Medical, a startup company developing optical coherence elastography for surgical applications. The other authors declare no conflicts of interest related to this article. (© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.)
Databáze:	MEDLINE
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