Tolerability of a new amino acid-based formula for children with IgE-mediated cow's milk allergy.

Autor: Nocerino R; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.; ImmunoNutritionLab at CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy., Di Scala C; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.; ImmunoNutritionLab at CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy., Coppola S; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.; ImmunoNutritionLab at CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy., Giglio V; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.; ImmunoNutritionLab at CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy., Carucci L; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.; ImmunoNutritionLab at CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy., Cosenza L; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.; ImmunoNutritionLab at CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy., Voto L; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy., Iannicelli AM; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy., Luzzetti A; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy., Berni Canani R; Department of Translational Medical Science, University of Naples Federico II, Naples, Italy. berni@unina.it.; ImmunoNutritionLab at CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy. berni@unina.it.; European Laboratory for the Investigation of Food-Induced Diseases, University of Naples, Federico II, Naples, Italy. berni@unina.it.; Task Force on Microbiome Studies, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy. berni@unina.it.
Jazyk: angličtina
Zdroj: Italian journal of pediatrics [Ital J Pediatr] 2021 Jul 03; Vol. 47 (1), pp. 151. Date of Electronic Publication: 2021 Jul 03.
DOI: 10.1186/s13052-021-01096-3
Abstrakt: Background: Amino acid-based formula (AAF) is a relevant dietary strategy for paediatric patients affected by cow's milk allergy (CMA). The present study was designed to evaluate the hypoallergenicity of a new AAF in children with immunoglobulin (Ig)E-mediated CMA.
Methods: According to the criteria provided by the American Academy of Pediatrics Subcommittee on Nutrition and Allergic Diseases, we designed a prospective trial in CMA children (aged 1-36 months) aimed to demonstrate the hypoallergenicity of the new AAF in 90% of subjects with 95% confidence during the double-blind, placebo-controlled challenge (DBPCFC). A skin prick test (SPT) with the new AAF was also performed.
Results: Twenty-nine children [all Caucasian, 55.2% male, mean age (±SD) 16.9 ± 5.7 months] were enrolled. The SPT and the DBPCFC with the new AAF were negative in all study subjects.
Conclusions: The study results support the hypoallergenicity of the new AAF. This formula could be considered an additional dietary option for non-breastfed children affected by CMA.
Trial Registration: The trial was registered in the ClinicalTrials.gov Protocol Registration System (ID number: NCT03909113 ).
Databáze: MEDLINE
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