Anti-fertility effect of levonorgestrel and/or quinestrol on striped field mouse (Apodemus agrarius): evidence from both laboratory and field experiments.

Autor: Chen X; Shaanxi Key Laboratory for Animal Conservation, Shaanxi Institute of Zoology, Xi'an, China.; College of Life Sciences, Shaanxi Normal University, Xi'an, China., Hou X; Shaanxi Key Laboratory for Animal Conservation, Shaanxi Institute of Zoology, Xi'an, China., Feng T; Shaanxi Key Laboratory for Animal Conservation, Shaanxi Institute of Zoology, Xi'an, China., Han N; Shaanxi Key Laboratory for Animal Conservation, Shaanxi Institute of Zoology, Xi'an, China., Wang J; Shaanxi Key Laboratory for Animal Conservation, Shaanxi Institute of Zoology, Xi'an, China., Chang G; Shaanxi Key Laboratory for Animal Conservation, Shaanxi Institute of Zoology, Xi'an, China.
Jazyk: angličtina
Zdroj: Integrative zoology [Integr Zool] 2022 Nov; Vol. 17 (6), pp. 1041-1052. Date of Electronic Publication: 2021 Jul 28.
DOI: 10.1111/1749-4877.12568
Abstrakt: The effect of combined levonorgestrel (P) and quinestrol (E) on the fertility of striped field mouse (Apodemus agrarius) has not been evaluated. We performed a series of experiments in both the laboratory and field to assess the effect of P and/or E on the fertility of A. agrarius. In the laboratory, to test the time-dependent anti-fertility effects of P and E, as well as their mixtures, 90 male striped field mice were randomly assigned to 6 treatment groups (n = 60), and a control group (n = 30). Mice in 3 treatment groups were administered 1 of the 3 compounds (1 mg⋅kg - 1 [body weight] EP-1, 0.34 mg⋅kg -1 E, 0.66 mg⋅kg -1 P) for 3 successive days (another half for 7 successive days) via oral gavage; mice were then sacrificed 15 and 45 days after initiating the gavage treatment. Our findings indicated that E and EP-1 treatment, but not P or control treatment, significantly decreased the sperm count in the caudal epididymis, as well as the weight of the testes, epididymides, and seminal vesicles. Additionally, fertile female mice mated with E- and EP-1-treated males produced smaller pups. These data indicate that E and EP-1 can induce infertility in male A. agrarius. In the field, the population density of A. agrarius was significantly influenced by EP-1, and the rodent density in the treatment group was lower than that in the control group. Overall, our results indicate that EP-1 is an effective contraceptive in A. agrarius, a dominant rodent species in the farmland.
(© 2021 International Society of Zoological Sciences, Institute of Zoology/Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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