The quality assessment of the University hospital bone bank in Central Serbia: the second audit after fourteen years.

Autor: Zeljko SL; Department of Arthroplasty, Clinic for Orthopaedic and Trauma Surgery, University Clinical Center Kragujevac, Zmaj Jovina 30, 34000, Kragujevac, Serbia. zeljko.stepanovic@medf.kg.ac.rs.; Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia. zeljko.stepanovic@medf.kg.ac.rs., Branko RM; Department of Arthroplasty, Clinic for Orthopaedic and Trauma Surgery, University Clinical Center Kragujevac, Zmaj Jovina 30, 34000, Kragujevac, Serbia.; Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia.
Jazyk: angličtina
Zdroj: Cell and tissue banking [Cell Tissue Bank] 2022 Jun; Vol. 23 (2), pp. 285-291. Date of Electronic Publication: 2021 Jul 02.
DOI: 10.1007/s10561-021-09942-8
Abstrakt: We analyzed the prevalence and predisposing factors for the overall rejection rate after retrieval of 267 fresh femoral head allografts over the past 7 years. The present study aimed to assess the quality system of institutional bone banking that can provide high-standard allografts with a low infection rate. Retrospective analysis of bone banking from June 2013 to December 2019 was conducted on 267 donors and 153 recipients. Of the 267 donated femoral heads, 74 were rejected, giving an overall rejection rate of 27.71%. The leading cause of allograft rejection was the inability to perform serology tests due to donor death; the absence of serological tests itself, and the donor refusal to perform the serology 6-month retest in 42 donors (15.72%). At retrieval, 12 allografts were positive, giving an overall contamination rate of 4.49%. Seven (2.62%) of the 267 allografts failed the blood screening tests. Thirteen allografts (4.86%) were discarded because of suspected damage to the packaging or disuse during surgery. An infection rate of 1.30% was found following transplantation. Over the past 7 years of bone banking, our results show that the overall rejection rate and the allograft-related infection rate correlate with international standards. The leading cause of allograft rejection was the inability to perform serology tests due to donor death and their refusal to perform the serology retests. Besides stringent aseptic allograft handling, donor motivation to participate in bone banking is extremely important for its efficient functioning.
(© 2021. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
Externí odkaz: