Comparison of Quantitative Flow Ratio and Invasive Physiology Indices in a Diverse Population at a Tertiary United States Hospital.

Autor: Finizio M; Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA., Melaku GD; Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA., Kahsay Y; Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA., Beyene S; Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA., Kuku KO; Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA., Ben-Dor I; Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA., Hashim H; Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA., Waksman R; Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA., Garcia-Garcia HM; Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA. Electronic address: hector.m.garciagarcia@medstar.net.
Jazyk: angličtina
Zdroj: Cardiovascular revascularization medicine : including molecular interventions [Cardiovasc Revasc Med] 2021 Nov; Vol. 32, pp. 1-4. Date of Electronic Publication: 2021 Jun 25.
DOI: 10.1016/j.carrev.2021.06.115
Abstrakt: Background: Quantitative flow ratio (QFR) is a technology to evaluate the coronary stenosis significance on 3-dimensional quantitative coronary angiography. The aim of this study is to evaluate and compare the QFR versus fractional flow reserve (FFR) and/or instantaneous free-wave ratio (iFR) in a US population with a fair African American population representation.
Methods and Results: This was a retrospective, observational and single-center study that enrolled 100 patients who underwent coronary angiography. The diagnostic performance of QFR in terms of sensitivity was 0.80 (95%CI 0.64-0.97) and specificity was 0.95 (95% CI 0.90-1.00), the positive predictive value (PPV) was 0.83 (0.68-0.98), while the negative predictive value (NPV) was 0.94 (0.88-0.99). The overall accuracy was 0.91 and area under the curve (AUC) was 0.92 (95% CI 0.87-0.97). The R-squared was 0.54 and the Bland-Altman plot showed a bias of 0.0016 (SD 0.063) and limits of agreement (LOA): Upper LOA 0.13 and Lower LOA -0.12. In African Americans (n = 33), accuracy, AUC, sensitivity, specificity (94%; 0.90 [0.80-1.00]; 0.90 [0.71-1.00]; 0.96 [0.87-1.00], respectively) were better than those for the overall population.
Conclusions: In a US-based representative population, vessel QFR accuracy and agreement with FFR as reference is high. Diagnostic performance of QFR in African Americans is also excellent.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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