Effect of glutamine supplementation on inflammatory markers in critically ill patients supported with enteral or parenteral feeding.

Autor: Gholamalizadeh M; Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Tabrizi R; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran., Rezaei S; Department of Clinical Nutrition, Student Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.; Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran., Badeli M; Department of Nutrition, Urmia University of Medical Science, Urmia, Iran., Shadnoush M; Department of Clinical Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Jarrahi AM; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Doaei S; Reproductive Health Research Center, Department of Obstetrics & Gynecology, Al-zahra hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Jazyk: angličtina
Zdroj: JPEN. Journal of parenteral and enteral nutrition [JPEN J Parenter Enteral Nutr] 2022 Jan; Vol. 46 (1), pp. 61-68. Date of Electronic Publication: 2021 Aug 16.
DOI: 10.1002/jpen.2217
Abstrakt: Background: Glutamine plays an important role in acute catabolic conditions in critically ill patients. This meta-analysis aimed to investigate the effect of glutamine supplementation on inflammatory markers in critically ill patients supported with enteral feeding (EN) or parenteral feeding (PN).
Methods: PubMed, Web of Science, Scopus, and Embase were explored to identify the studies investigating the effect of glutamine on serum inflammatory markers in intensive care unit patients. All randomized clinical trials that assessed the effect of glutamine supplementation on "inflammatory markers" in EN or PN were included in the study. Because a small number of studies were included, SE was adjusted for overall effect size by using the Knapp-Hartung method.
Results: In this study, 2728 eligible studies were initially included, and 10 eligible case-control studies were finally enrolled for further investigations. There was a statistical reduction between preintervention and postintervention CRP levels (standardized mean difference [SMD] = -0.38 mg/L; 95% CI, -0.72 to -0.03). No significant association was found between L-glutamine supplementation in the EN/PN and interleukin 6 (IL-6) (SMD = -0.58 pg/ml; 95% CI, -2.15 to 0.99) and tumor necrosis factor alpha (TNF-α) (SMD = 2.69 pg/ml; 95% CI, -9.66 to 15.03) compared with the control group.
Conclusions: This study identified that glutamine supplementation might have an important effect on CRP in acute conditions and no significant effect on IL-6 and TNF-α in acute conditions.
(© 2021 American Society for Parenteral and Enteral Nutrition.)
Databáze: MEDLINE
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