Challenges, highlights, and opportunities in cellular transplantation: A white paper of the current landscape.

Autor: Parsons RF; Department of Surgery, Emory Transplant Center, Emory University School of Medicine, Atlanta, Georgia., Baquerizo A; Scripps Center for Cell and Organ Transplantation, La Jolla, California., Kirchner VA; Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota., Malek S; Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Desai CS; Division of Transplantation, Department of Surgery, University of North Carolina, Chapel Hill, North Carolina., Schenk A; Division of Transplantation, Department of Surgery, Ohio State University, Columbus, Ohio., Finger EB; Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota., Brennan TV; Department of Surgery, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, California., Parekh KR; Division of Cardiothoracic Surgery, Department of Surgery, Carver College of Medicine, University of Iowa, Iowa City, Iowa., MacConmara M; Division of Surgical Transplantation, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas., Brayman K; Division of Transplantation, Department of Surgery, University of Virginia, Charlottesville, Virginia., Fair J; Division of Transplant Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, Texas., Wertheim JA; Departments of Surgery and Biomedical Engineering, University of Arizona Health Sciences, Tucson, Arizona.
Jazyk: angličtina
Zdroj: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2021 Oct; Vol. 21 (10), pp. 3225-3238. Date of Electronic Publication: 2021 Jul 22.
DOI: 10.1111/ajt.16740
Abstrakt: Although cellular transplantation remains a relatively small field compared to solid organ transplantation, the prospects for advancement in basic science and clinical care remain bountiful. In this review, notable historical events and the current landscape of the field of cellular transplantation are reviewed with an emphasis on islets (allo- and xeno-), hepatocytes (including bioartificial liver), adoptive regulatory immunotherapy, and stem cells (SCs, specifically endogenous organ-specific and mesenchymal). Also, the nascent but rapidly evolving field of three-dimensional bioprinting is highlighted, including its major processing steps and latest achievements. To reach its full potential where cellular transplants are a more viable alternative than solid organ transplants, fundamental change in how the field is regulated and advanced is needed. Greater public and private investment in the development of cellular transplantation is required. Furthermore, consistent with the call of multiple national transplant societies for allo-islet transplants, the oversight of cellular transplants should mirror that of solid organ transplants and not be classified under the unsustainable, outdated model that requires licensing as a drug with the Food and Drug Administration. Cellular transplantation has the potential to bring profound benefit through progress in bioengineering and regenerative medicine, limiting immunosuppression-related toxicity, and providing markedly reduced surgical morbidity.
(© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons.)
Databáze: MEDLINE
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