Are the FTO Gene Polymorphisms Associated with Colorectal Cancer? A Meta-analysis.

Autor: Gholamalizadeh M; Students Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Tabrizi R; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran., Bourbour F; Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Rezaei S; Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.; Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran., Pourtaheri A; School of Medicine, Mashhad University of Medical Sciences, Tehran, Iran., Badeli M; Department of Nutrition, Urmia University of Medical Science, Urmia, Iran., Jarrahi SAM; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Akbari ME; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Kalantari N; Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Doaei S; Research Center of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran. Sdoaee@yahoo.com.
Jazyk: angličtina
Zdroj: Journal of gastrointestinal cancer [J Gastrointest Cancer] 2021 Sep; Vol. 52 (3), pp. 846-853. Date of Electronic Publication: 2021 Jul 01.
DOI: 10.1007/s12029-021-00651-9
Abstrakt: Background: Colorectal cancer (CRC) is reported to be associated with some gene polymorphisms. However, the effect of the fat mass and obesity associated (FTO) gene on colorectal cancer is not yet clear. This meta-analysis aimed to investigate the association of the FTO gene polymorphism and colorectal cancer.
Methods: PubMed, Web of science, Scopus, and Embase were explored to identify the studies investigating the relationship between rs9939609 and rs17817449 polymorphisms of FTO gene and colorectal cancer, and the published papers from 2000 to 2019 were collected. This meta-analysis was conducted by using a random-effects model for the best estimation of the desired outcomes.
Results: In this study, 1528 studies were initially included and five eligible case-control studies including 13,460 cases and 22,578 controls were eligible for further analyses. No significant association was found between risk allele of FTO rs9939609 (OR = 0.98, 0.87-1.1) and rs17817449 (OR = 0.9, 0.79-1.03) polymorphisms and colorectal cancer risk. The subgroup analyses considering the source of the control group and race found no significant association between FTO polymorphisms and the risk of colon cancer.
Conclusions: This study indicated that rs9939609 and rs17817449 FTO gene polymorphisms are not associated with colorectal cancer risk. Individual studies involving different FTO polymorphisms are needed to further evaluation of the associations between the FTO gene and colon cancer.
(© 2021. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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