FSH Level and Changes in Bone Mass and Body Composition in Older Women and Men.

Autor:	Wu KC; Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.; Endocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA 94121, USA., Ewing SK; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143, USA., Li X; Program of Advanced Musculoskeletal Imaging, Cleveland Clinic, Cleveland, OH 44195, USA., Sigurðsson S; Icelandic Heart Association Research Institute, 201 Kópavogur, Iceland., Guðnason V; Icelandic Heart Association Research Institute, 201 Kópavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Kado DM; Department of Medicine, Stanford University, Stanford, CA 94305, USA.; Geriatric Research Education and Clinical Center, Veterans Affairs Health Care System, Palo Alto, CA 94304, USA., Hue TF; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143, USA., Woods GN; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.; Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA., Veldhuis-Vlug AG; Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME 04074, USA.; Center for Bone Quality, Department of Endocrinology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Vittinghoff E; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143, USA., Zaidi M; The Mount Sinai Bone Program and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rosen CJ; Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME 04074, USA., Lang T; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA., Kim TY; Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.; Endocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA 94121, USA., Schwartz AV; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143, USA., Schafer AL; Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.; Endocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA 94121, USA.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143, USA.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2021 Sep 27; Vol. 106 (10), pp. 2876-2889.
DOI:	10.1210/clinem/dgab481
Abstrakt:	Context: FSH may have independent actions on bone remodeling and body fat regulation. Cross-sectionally, we have shown that serum FSH is associated with bone mineral density (BMD) and body fat in older postmenopausal women, but it remains unknown whether FSH predicts bone and fat changes. Objective: We examined whether baseline FSH level is associated with subsequent bone loss or body composition changes in older adults. Setting, Design, Participants: We studied 162 women and 158 men (mean age 82 ± 4 years) from the Age, Gene/Environment Susceptibility (AGES)-Bone Marrow Adiposity cohort, a substudy of the AGES-Reykjavik Study of community-dwelling older adults. Skeletal health and body composition were characterized at baseline and 3 years later. Main Outcomes: Annualized change in BMD and body composition by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). Models were adjusted for serum estradiol and testosterone levels. Results: There was no evidence for an association between baseline FSH level and change in BMD or body composition by DXA or QCT. For femoral neck areal BMD, adjusted mean difference (95% CI) per SD increase in FSH was 1.3 (-0.7 to 3.3) mg/cm2/y in women, and -0.2 (-2.6 to 2.2) mg/cm2/y in men. For visceral fat, adjusted mean difference (95% CI) per SD increase in FSH was 1.80 (-0.03 to 3.62) cm2/y in women, and -0.33 (-3.73 to 3.06) cm2/y in men. Conclusions: Although cross-sectional studies and studies in perimenopausal women have demonstrated associations between FSH and BMD and body composition, in older adults, FSH level is not associated with bone mass or body composition changes. (Published by Oxford University Press on behalf of the Endocrine Society 2021.)
Databáze:	MEDLINE
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