| Autor: |
Bazaldúa-Rodríguez AF; Laboratorio de Fitoquímica, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León (UANL), Av. Universidad S/N, Cd. Universitaria, San Nicolás de los Garza C.P. 66455, Nuevo León, Mexico., Quintanilla-Licea R; Laboratorio de Fitoquímica, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León (UANL), Av. Universidad S/N, Cd. Universitaria, San Nicolás de los Garza C.P. 66455, Nuevo León, Mexico., Verde-Star MJ; Laboratorio de Fitoquímica, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León (UANL), Av. Universidad S/N, Cd. Universitaria, San Nicolás de los Garza C.P. 66455, Nuevo León, Mexico., Hernández-García ME; Laboratorio de Fisiología Celular y Molecular, Centro de Investigaciones Biomédicas del Noreste (CIBIN), Dos de Abril Esquina con San Luis Potosí, Monterrey C.P. 64720, Nuevo León, Mexico., Vargas-Villarreal J; Laboratorio de Biología y Fisiología Molecular y Celular, Centro de Investigaciones Biomédicas del Noreste (CIBIN), Dos de Abril Esquina con San Luis Potosí, Monterrey C.P. 64720, Nuevo León, Mexico., Garza-González JN; Departamento de Ciencias Básicas, Universidad de Monterrey, Av. Ignacio Morones Prieto 4500 Pte., San Pedro Garza García C.P. 66238, Nuevo León, Mexico. |
| Abstrakt: |
Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of Ruta chalepensis (Rutaceae) against E. histolytica . The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of R. chalepensis afforded the furocoumarins rutamarin ( 1 ) and chalepin ( 2 ), which showed high antiprotozoal activity on Entamoeba histolytica trophozoites employing in vitro tests (IC 50 values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin. |
