| Autor: |
Gvozdeva OV; Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences, P.O. Box 267, 630501 Krasnoobsk, Russia., Achasova KM; Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences, P.O. Box 267, 630501 Krasnoobsk, Russia., Litvinova NA; Faculty of General Medicine, Kemerovo State Medical University, 650001 Kemerovo, Russia., Kozhevnikova EN; Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences, P.O. Box 267, 630501 Krasnoobsk, Russia.; Scientific Research Institute of Neurosciences and Medicine, 630117 Novosibirsk, Russia., Litvinova EA; Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences, P.O. Box 267, 630501 Krasnoobsk, Russia.; Scientific Research Institute of Neurosciences and Medicine, 630117 Novosibirsk, Russia. |
| Abstrakt: |
Scent signals play an important role in the life of rodents. The scent of the opposite sex can modulate immunity. In mice populations with natural specific pathogens, in males, the scent of a female leads to a redistribution of leukocytes between the lung and the blood, resistance to the influenza virus, and a decrease in antibody production, but not in the development of inflammation induced by bacterial endotoxins. This study demonstrates the effect of the scent of soiled bedding of specific pathogen-free (SPF) status female mice on the percentage of different types of leukocytes in the blood, the expression of Nos2 , Arg1 , and Foxp3 genes, and the presence of M1/M2 macrophages in the lungs of male BALB/c mice. The scent of the female SPF mice caused a redistribution between T- and B-cells in the blood, the increase in the expression of Nos2 , Arg1 genes, and the percentage of M1 type macrophages in the lung, but did not affect the different types of T-cells in the periphery or the lungs. Activation of macrophages in the lung is part of mucosal immunity, which is necessary for males as an adaptive mechanism to prevent potential infection during the search for a sexual partner. |
