| Autor: |
Latimer DR; Department of Psychiatry and Behavioral Medicine Louisiana State University Health Science Center Baton Rouge, Baton Rouge, LA 70808, USA., Edinoff AN; Department of Psychiatry and Behavioral Medicine, Louisiana State University Health Science Center Shreveport, Shreveport, LA 71103, USA., Ruff RD; School of Medicine, Louisiana State University Health Sheveport, Sheveport, LA 71103, USA., Rooney KC; School of Medicine, Louisiana State University Health Sheveport, Sheveport, LA 71103, USA., Penny KM; School of Medicine, Louisiana State University Health Sheveport, Sheveport, LA 71103, USA., Patel SB; School of Medicine, Louisiana State University Health Sheveport, Sheveport, LA 71103, USA., Sabbenahalli S; Department of Psychiatry and Behavioral Medicine Louisiana State University Health Science Center Baton Rouge, Baton Rouge, LA 70808, USA., Kaye AM; Thomas J. Long School of Pharmacy and Health Sciences, Department of Pharmacy Practice, University of the Pacific, Stockton, CA 94103, USA., Cornett EM; Department of Anesthesiology, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA., Viswanath O; College of Medicine-Phoenix, University of Arizona, Phoenix, AZ 85004, USA.; Department of Anesthesiology, Creighton University School of Medicine, Omaha, NE 68124, USA.; Valley Anesthesiology and Pain Consultants, Envision Physician Services, Phoenix, AZ 85004, USA., Urits I; Department of Anesthesiology, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.; Southcoast Physicians Group Pain Medicine, Southcoast Health, Wareham, MA 02720, USA., Kaye AD; Department of Anesthesiology, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA. |
| Abstrakt: |
Medical management of epilepsy seeks to eliminate or to reduce the frequency of seizures, help patients maintain a normal lifestyle, and maintain psychosocial and occupational activities, while avoiding the negative side effects of long-term treatment. Current FDA approved drugs have been shown to have similar efficacy; however, they all share a commonality of having side effects that have the potential to significantly reduce a patient's quality of life. Cenobamate, a newly-FDA approved drug used to treat partial-onset seizures in adult patients, has demonstrated promise in that it works on two proposed mechanisms that are commonly associated with epilepsy. Cenobamate acts as a positive allosteric modulator of the GABA A ion channels and is effective in reducing repetitive neuronal firing by inhibition of voltage-gated sodium channels, although the complete mechanism of action is currently unknown. The efficacy of Cenobamate with its low toxicity and adverse drug reaction profile emphasizes the need to further evaluate antiepileptic therapies containing sulfamoylphenyl and/or carbamate moieties in their chemical structure. Recent studies have found more patients to be seizure free during the maintenance period when compared to placebo. The most common side effects reported in with Cenobamate are somnolence, dizziness, headache, nausea, and fatigue. There are currently ongoing phase III studies looking to further evaluate the long-term benefits of Cenobamate and investigate adverse events. |
