Pyridazino-1,3a,6a-Triazapentalenes as Versatile Fluorescent Probes: Impact of Their Post-Functionalization and Application for Cellular Imaging.

Autor:	Sirbu D; Institut de Chimie Organique et Analytique-ICOA UMR7311, Rue de Chartres, CEDEX 2, 45100 Orléans, France., Chopin N; Institut de Chimie Organique et Analytique-ICOA UMR7311, Rue de Chartres, CEDEX 2, 45100 Orléans, France., Martinić I; Centre de Biophysique Moléculaire CNRS UPR 4301, Rue Charles Sadron, CEDEX 2, 45071 Orléans, France., Ndiaye M; Institut de Chimie Organique et Analytique-ICOA UMR7311, Rue de Chartres, CEDEX 2, 45100 Orléans, France., Eliseeva SV; Centre de Biophysique Moléculaire CNRS UPR 4301, Rue Charles Sadron, CEDEX 2, 45071 Orléans, France., Hiebel MA; Institut de Chimie Organique et Analytique-ICOA UMR7311, Rue de Chartres, CEDEX 2, 45100 Orléans, France., Petoud S; Centre de Biophysique Moléculaire CNRS UPR 4301, Rue Charles Sadron, CEDEX 2, 45071 Orléans, France., Suzenet F; Institut de Chimie Organique et Analytique-ICOA UMR7311, Rue de Chartres, CEDEX 2, 45100 Orléans, France.
Jazyk:	angličtina
Zdroj:	International journal of molecular sciences [Int J Mol Sci] 2021 Jun 21; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 21.
DOI:	10.3390/ijms22126645
Abstrakt:	Pyridazino-1,3a,6a-triazapentalenes (PyTAP) are compact fused 6/5/5 tricyclic scaffolds which exhibit promising fluorescent properties. Chemically stable, they can be post-functionalized using standard Pd-catalyzed cross-coupling chemistry. Several original PyTAP bearing additional unsaturated substituents in positions 2 and 8 were synthetized and their spectroscopic properties analyzed. They have been successfully tested as fluorescent probes for cellular imaging.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF