The Unusual Role of Pro in Cu(II) Binding by His 2 -Cyclopentapeptide.

Autor: Pieniężna A; Department of Inorganic Chemistry, Wroclaw Medical University, Borowska 211A, 50-552 Wrocław, Poland., Kotynia A; Department of Inorganic Chemistry, Wroclaw Medical University, Borowska 211A, 50-552 Wrocław, Poland., Brasuń J; Department of Inorganic Chemistry, Wroclaw Medical University, Borowska 211A, 50-552 Wrocław, Poland.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2021 Jun 21; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 21.
DOI: 10.3390/ijms22126628
Abstrakt: In this paper, we present findings from studying the interaction of copper(II) ions with the His 2 -cyclopentapeptide and the role of proline used for the purpose of potentiometric titration and UV-Vis, CD and EPR spectroscopic measurements. Experiments of two homodetic peptides differing by one amino acid residue were conducted for a ligand to metal ratio of 1:1 in the pH range 2.5-11.0. The presented studies reveal that peptides form only mononuclear complexes, and the CuH 2 L complex appears in the system first (for both L1 and L2). Study results show that the presence of Pro influences the structure of formed complexes and their stabilities and has a strong impact on the efficiency of copper(II) coordination.
Databáze: MEDLINE
Externí odkaz: