| Autor: |
Yaglova NV; Laboratory of Endocrine System Development, Federal State Budgetary Scientific Institution 'Research Institute of Human Morphology', 117418 Moscow, Russia., Obernikhin SS; Laboratory of Endocrine System Development, Federal State Budgetary Scientific Institution 'Research Institute of Human Morphology', 117418 Moscow, Russia., Tsomartova DA; Laboratory of Endocrine System Development, Federal State Budgetary Scientific Institution 'Research Institute of Human Morphology', 117418 Moscow, Russia.; Department of Histology, Cytology, and Embryology, Federal State Funded Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia., Nazimova SV; Laboratory of Endocrine System Development, Federal State Budgetary Scientific Institution 'Research Institute of Human Morphology', 117418 Moscow, Russia., Yaglov VV; Laboratory of Endocrine System Development, Federal State Budgetary Scientific Institution 'Research Institute of Human Morphology', 117418 Moscow, Russia., Tsomartova ES; Laboratory of Endocrine System Development, Federal State Budgetary Scientific Institution 'Research Institute of Human Morphology', 117418 Moscow, Russia.; Department of Histology, Cytology, and Embryology, Federal State Funded Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia., Chereshneva EV; Department of Histology, Cytology, and Embryology, Federal State Funded Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia., Ivanova MY; Department of Histology, Cytology, and Embryology, Federal State Funded Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia., Lomanovskaya TA; Department of Histology, Cytology, and Embryology, Federal State Funded Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia. |
| Abstrakt: |
Dichlorodiphenyltrichloroethane (DDT) is a persistent organic pollutant and one of the most widespread endocrine disrupting chemicals. The impact of low-dose exposure to DDT on the morphogenesis of the adrenal gland is still poorly understood. The development and function of zona glomerulosa in rats has been found to be associated with changes in the expression of the transcription factor Oct4 (Octamer 4), which is the most important player in cell pluripotency. The aim of the study was to investigate the morphogenesis and function of rat adrenal zona glomerulosa in rats exposed to low doses of DDT during prenatal and postnatal development and to determine the possible role of Oct4 in DDT-mediated structural and functional changes. The DDT-exposed rats demonstrated slower development and lower functional activity of the zona glomerulosa during the pubertal period associated with higher expression of Oct4. Further, accelerated growth and restoration of hormone production was associated with, firstly, a decrease in Oct4 expressing cells and secondly, the loss of the inverse relationship between basal aldosterone levels and the number of Oct4 expressing cells. Thus, the transcriptional factor Oct4 exhibited an altered pattern of expression in the DDT-exposed rats during postnatal development. The results of the study uncover a novel putative mechanism by which low doses of DDT disrupt the development of adrenal zona glomerulosa. |
