Geographical Distribution and Genetic Diversity of Bank Vole Hepaciviruses in Europe.

Autor: Schneider J; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany.; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Hoffmann B; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany., Fevola C; Research and Innovation Centre, Department of Biodiversity and Molecular Ecology, Fondazione Edmund Mach, 38098 San Michele all'Adige, Italy.; Department of Virology, Faculty of Medicine, University of Helsinki, 00100 Helsinki, Finland., Schmidt ML; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany.; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Imholt C; Vertebrate Research, Federal Research Centre for Cultivated Plants, Institute for Plant Protection in Horticulture and Forests, Julius Kühn-Institute (JKI), Toppheideweg 88, 48161 Münster, Germany., Fischer S; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany., Ecke F; Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, 90183 Umeå, Sweden., Hörnfeldt B; Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, 90183 Umeå, Sweden., Magnusson M; Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, 90183 Umeå, Sweden., Olsson GE; Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, 90183 Umeå, Sweden.; Unit for Nature Conservation, County Administrative Board of Halland County, 30004 Halmstad, Sweden., Rizzoli A; Research and Innovation Centre, Department of Biodiversity and Molecular Ecology, Fondazione Edmund Mach, 38098 San Michele all'Adige, Italy., Tagliapietra V; Research and Innovation Centre, Department of Biodiversity and Molecular Ecology, Fondazione Edmund Mach, 38098 San Michele all'Adige, Italy., Chiari M; Direzione Generale Welfare, U.O. Veterinaria, Piazza Città di Lombardia 1, 20124 Milan, Italy., Reusken C; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), 3720 Bilthoven, The Netherlands., Bužan E; Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, 6000 Koper, Slovenia.; Environmental Protection College, 3320 Velenje, Slovenia., Kazimirova M; Institute of Zoology, Slovak Academy of Sciences (SAS), 81438 Bratislava, Slovakia., Stanko M; Institute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 04001 Košice, Slovakia., White TA; Lancaster Environment Centre, Lancaster University, Lancaster LA2 0QZ, UK., Reil D; Vertebrate Research, Federal Research Centre for Cultivated Plants, Institute for Plant Protection in Horticulture and Forests, Julius Kühn-Institute (JKI), Toppheideweg 88, 48161 Münster, Germany., Obiegala A; Institute of Animal Hygiene and Veterinary Public Health, University of Leipzig, 04109 Leipzig, Germany., Meredith A; Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh EH8 9AB, UK.; Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC 3052, Australia., Drexler JF; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, Sechenov University, 119991 Moscow, Russia.; German Centre for Infection Research (DZIF), Associated Partner Site Berlin, 10117 Berlin, Germany., Essbauer S; Department Virology and Rickettsiology, Bundeswehr Institute of Microbiology, 80937 Munich, Germany., Henttonen H; Natural Resources Institute Finland (LUKE), 00791 Helsinki, Finland., Jacob J; Vertebrate Research, Federal Research Centre for Cultivated Plants, Institute for Plant Protection in Horticulture and Forests, Julius Kühn-Institute (JKI), Toppheideweg 88, 48161 Münster, Germany., Hauffe HC; Research and Innovation Centre, Department of Biodiversity and Molecular Ecology, Fondazione Edmund Mach, 38098 San Michele all'Adige, Italy., Beer M; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany., Heckel G; Institute of Ecology and Evolution, University of Bern, 3012 Bern, Switzerland., Ulrich RG; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2021 Jun 28; Vol. 13 (7). Date of Electronic Publication: 2021 Jun 28.
DOI: 10.3390/v13071258
Abstrakt: The development of new diagnostic methods resulted in the discovery of novel hepaciviruses in wild populations of the bank vole ( Myodes glareolus , syn. Clethrionomys glareolus ). The naturally infected voles demonstrate signs of hepatitis similar to those induced by hepatitis C virus (HCV) in humans. The aim of the present research was to investigate the geographical distribution of bank vole-associated hepaciviruses (BvHVs) and their genetic diversity in Europe. Real-time reverse transcription polymerase chain reaction (RT-qPCR) screening revealed BvHV RNA in 442 out of 1838 (24.0%) bank voles from nine European countries and in one of seven northern red-backed voles ( Myodes rutilus , syn. Clethrionomys rutilus ). BvHV RNA was not found in any other small mammal species (n = 23) tested here. Phylogenetic and isolation-by-distance analyses confirmed the occurrence of both BvHV species ( Hepacivirus F and Hepacivirus J ) and their sympatric occurrence at several trapping sites in two countries. The broad geographical distribution of BvHVs across Europe was associated with their presence in bank voles of different evolutionary lineages. The extensive geographical distribution and high levels of genetic diversity of BvHVs, as well as the high population fluctuations of bank voles and occasional commensalism in some parts of Europe warrant future studies on the zoonotic potential of BvHVs.
Databáze: MEDLINE
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