Systems Biology and Bile Acid Signalling in Microbiome-Host Interactions in the Cystic Fibrosis Lung.

Autor:	Woods DF; BIOMERIT Research Centre, School of Microbiology, University College Cork, T12 YN60 Cork, Ireland., Flynn S; BIOMERIT Research Centre, School of Microbiology, University College Cork, T12 YN60 Cork, Ireland., Caparrós-Martín JA; Human Microbiome Programme, School of Pharmacy and Biomedical Sciences, Curtin University, Perth 6102, Australia.; Curtin Health Innovation Research Institute (CHIRI), Curtin University, Perth 6102, Australia.; Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth 6009, Australia., Stick SM; Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth 6009, Australia.; Telethon Kids Institute, The University of Western Australia, Perth 6009, Australia.; School of Biomedical Sciences, Faculty of Health and Medical Sciences, The University of Western Australia, Perth 6009, Australia.; Department of Respiratory Medicine and Sleep Medicine, Perth Children's Hospital, Perth 6009, Australia., Reen FJ; BIOMERIT Research Centre, School of Microbiology, University College Cork, T12 YN60 Cork, Ireland.; School of Microbiology, University College Cork, T12 YN60 Cork, Ireland.; Synthesis and Solid State Pharmaceutical Centre, University College Cork, T12 YN60 Cork, Ireland., O'Gara F; BIOMERIT Research Centre, School of Microbiology, University College Cork, T12 YN60 Cork, Ireland.; Human Microbiome Programme, School of Pharmacy and Biomedical Sciences, Curtin University, Perth 6102, Australia.; Curtin Health Innovation Research Institute (CHIRI), Curtin University, Perth 6102, Australia.; Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth 6009, Australia.; Synthesis and Solid State Pharmaceutical Centre, University College Cork, T12 YN60 Cork, Ireland.
Jazyk:	angličtina
Zdroj:	Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2021 Jun 24; Vol. 10 (7). Date of Electronic Publication: 2021 Jun 24.
DOI:	10.3390/antibiotics10070766
Abstrakt:	The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbalances in these communities can contribute to the pathogenesis of lung disease. How these imbalances occur and establish is largely unknown. This review is focused on the genetically inherited condition of Cystic Fibrosis (CF). Understanding the microbial and host-related factors that govern the establishment of chronic CF lung inflammation and pathogen colonisation is essential. Specifically, dissecting the interplay in the inflammation-pathogen-host axis. Bile acids are important host derived and microbially modified signal molecules that have been detected in CF lungs. These bile acids are associated with inflammation and restructuring of the lung microbiota linked to chronicity. This community remodelling involves a switch in the lung microbiota from a high biodiversity/low pathogen state to a low biodiversity/pathogen-dominated state. Bile acids are particularly associated with the dominance of Proteobacterial pathogens. The ability of bile acids to impact directly on both the lung microbiota and the host response offers a unifying principle underpinning the pathogenesis of CF. The modulating role of bile acids in lung microbiota dysbiosis and inflammation could offer new potential targets for designing innovative therapeutic approaches for respiratory disease.
Databáze:	MEDLINE
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