Toxoplasma gondii Infection and Suicidal Behavior in People with Alcohol Consumption.

Autor:	Alvarado-Esquivel C; Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, Mexico., Estrada-Martínez S; Institute for Scientific Research 'Dr. Roberto Rivera-Damm', Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, Mexico., Pérez-Álamos AR; Institute for Scientific Research 'Dr. Roberto Rivera-Damm', Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, Mexico., Beristain-García I; Facultad de Enfermería y Obstetricia, Juárez University of Durango State, Blvd. Juan Pablo II 512, Durango 34000, Mexico., Alvarado-Félix ÁO; Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, Mexico., Alvarado-Félix GA; Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, Mexico., Sifuentes-Álvarez A; Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, Mexico.
Jazyk:	angličtina
Zdroj:	Pathogens (Basel, Switzerland) [Pathogens] 2021 Jun 10; Vol. 10 (6). Date of Electronic Publication: 2021 Jun 10.
DOI:	10.3390/pathogens10060734
Abstrakt:	We determined the association between T. gondii infection and suicidal behavior in people with alcohol consumption. One-thousand four-hundred and twenty-three people with alcohol consumption were screened for suicidal behavior and tested for anti- T. gondii IgG and IgM antibodies using commercially available enzyme-linked immunosorbent assays. Anti- T. gondii IgG antibodies were found in 34 of 224 (15.2%) individuals with suicidal ideation and in 118 (9.8%) of 1199 individuals without suicidal ideation (OR: 1.63; 95% CI: 1.08-2.47; p = 0.01). Seropositivity to T. gondii was associated with suicidal ideation in women (OR: 2.24; 95% CI: 1.33-3.78; p = 0.001) and in individuals aged ≤30 years (OR: 2.68; 95% CI: 1.22-5.87; p = 0.01) and >50 years (OR: 2.85; 95% CI: 1.19-6.77; p = 0.01). Anti- T. gondii IgG antibodies were found in 17 of 136 (12.5%) individuals with suicide attempts and in 135 (10.5%) of 1287 individuals without suicide attempts (OR: 1.21; 95% CI: 0.71-2.08; p = 0.47). Seroprevalence of T. gondii infection was associated with suicide attempts in women (OR: 1.88; 95% CI: 0.99-3.55; p = 0.04). No association between anti- T. gondii IgM and suicidal ideation or suicide attempts was found. Results suggest that T. gondii infection is associated with suicidal behavior in people with alcohol consumption.
Databáze:	MEDLINE
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