How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System.
| Autor: | Sajidah ES; Division of Nano Life Science in the Graduate School of Frontier Science Initiative, Kanazawa University, Kanazawa 920-1192, Japan., Lim K; WPI-Nano Life Science Institute, Kanazawa University, Kanazawa 920-1192, Japan., Wong RW; Division of Nano Life Science in the Graduate School of Frontier Science Initiative, Kanazawa University, Kanazawa 920-1192, Japan.; WPI-Nano Life Science Institute, Kanazawa University, Kanazawa 920-1192, Japan.; Cell-Bionomics Research Unit, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa 920-1192, Japan. |
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| Jazyk: | angličtina |
| Zdroj: | Cells [Cells] 2021 Jun 07; Vol. 10 (6). Date of Electronic Publication: 2021 Jun 07. |
| DOI: | 10.3390/cells10061424 |
| Abstrakt: | The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response. Viruses encode many factors that interact with the host nuclear transport receptors (NTRs) and the nucleoporins of the nuclear pore complex (NPC) to access the host nucleus. In this review, we discuss the viral factors and the host factors involved in the nuclear import and export of viral components. As nucleocytoplasmic shuttling is vital for the replication of many viruses, we also review several drugs that target the host nuclear transport machinery and discuss their feasibility for use in antiviral treatment. |
| Databáze: | MEDLINE |
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