Influence of Cerebral Vasodilation on Blood Reelin Levels in Growth Restricted Fetuses.

Autor: Pascual-Mancho J; Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, 28009 Madrid, Spain.; Health Research Institute Gregorio Marañón, 28009 Madrid, Spain.; Department of Obstetrics, Prenatal Diagnosis, Miguel Servet University Hospital, 50009 Zaragoza, Spain., Pintado-Recarte P; Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, 28009 Madrid, Spain.; Health Research Institute Gregorio Marañón, 28009 Madrid, Spain., Romero-Román C; Laboratory of Clinical Biochemistry, Albacete Hospital, 02006 Albacete, Spain., Morales-Camino JC; Laboratory of Clinical Biochemistry, Albacete Hospital, 02006 Albacete, Spain., Hernández-Martin C; Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, 28009 Madrid, Spain.; Health Research Institute Gregorio Marañón, 28009 Madrid, Spain., Bujan J; Ramón y Cajal Institute of Healthcare Research (IRYCIS), 28034 Madrid, Spain.; Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, 28801 Madrid, Spain., Ortega MA; Ramón y Cajal Institute of Healthcare Research (IRYCIS), 28034 Madrid, Spain.; Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, 28801 Madrid, Spain.; Pathological Anatomy Service, Central University Hospital of Defense-UAH, 28047 Madrid, Spain., De León-Luis J; Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.; Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, 28009 Madrid, Spain.; Health Research Institute Gregorio Marañón, 28009 Madrid, Spain.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2021 Jun 04; Vol. 11 (6). Date of Electronic Publication: 2021 Jun 04.
DOI: 10.3390/diagnostics11061036
Abstrakt: Fetal growth restriction (FGR) is one of the most important obstetric pathologies. It is frequently caused by placental insufficiency. Previous studies have shown a relationship between FGR and impaired new-born neurodevelopment, although the molecular mechanisms involved in this association have not yet been completely clarified. Reelin is an extracellular matrix glycoprotein involved in development of neocortex, hippocampus, cerebellum and spinal cord. Reelin has been demonstrated to play a key role in regulating perinatal neurodevelopment and to contribute to the emergence and development of various psychiatric pathologies, and its levels are highly influenced by pathological conditions of hypoxia. The purpose of this article is to study whether reelin levels in new-borns vary as a function of severity of fetal growth restriction by gestational age and sex. We sub-grouped fetuses in: normal weight group (Group 1, n = 17), FGR group with normal umbilical artery Doppler and cerebral redistribution at middle cerebral artery Doppler (Group 2, n = 9), and FGR with abnormal umbilical artery Doppler (Group 3, n = 8). Our results show a significant association of elevated Reelin levels in FGR fetuses with cerebral blood redistribution compared to the normal weight group and the FGR with abnormal umbilical artery group. Future research should focus on further expanding the knowledge of the relationship of reelin and its regulated products with neurodevelopment impairment in new-borns with FGR and should include larger and more homogeneous samples and the combined use of different in vivo techniques in neonates with impaired growth during their different adaptive phases.
Databáze: MEDLINE
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