Transcutaneous Drug Delivery Systems Based on Collagen/Polyurethane Composites Reinforced with Cellulose.

Autor: Anghel N; 'Petru Poni' Institute of Macromolecular Chemistry, Grigore Ghica-Voda 41, 700487 Iasi, Romania., Dinu VM; 'Petru Poni' Institute of Macromolecular Chemistry, Grigore Ghica-Voda 41, 700487 Iasi, Romania., Verestiuc L; Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 9-13 Kogalniceanu Street, 700454 Iasi, Romania., Spiridon IA; Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 9-13 Kogalniceanu Street, 700454 Iasi, Romania.
Jazyk: angličtina
Zdroj: Polymers [Polymers (Basel)] 2021 Jun 02; Vol. 13 (11). Date of Electronic Publication: 2021 Jun 02.
DOI: 10.3390/polym13111845
Abstrakt: Designing composites based on natural polymers has attracted attention for more than a decade due to the possibility to manufacture medical devices which are biocompatible with the human body. Herein, we present some biomaterials made up of collagen, polyurethane, and cellulose doped with lignin and lignin-metal complex, which served as transcutaneous drug delivery systems. Compared with base material, the compressive strength and the elastic modulus of biocomposites comprising lignin or lignin-metal complex were significantly enhanced; thus, the compressive strength increased from 61.37 to 186.5 kPa, while the elastic modulus increased from 0.828 to 1.928 MPa. The release of ketokonazole from the polymer matrix follows a Korsmeyer-Peppas type kinetics with a Fickian diffusion. All materials tested were shown to be active against pathogenic microorganisms. The mucoadhesiveness, bioadhesiveness, mechanical resistance, release kinetic, and antimicrobial activity make these biocomposites to be candidates as potential systems for controlled drug release.
Databáze: MEDLINE
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