| Autor: |
Fiorentina P; Faculty of BioScience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy., Martino C; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale' Via Campo Boario, 64100 Teramo, Italy., Mancini Y; Faculty of BioScience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy., De Iorio MG; Department of Veterinary Medicine DIMEVET, University of Milan, 20133 Milan, Italy., Williams JL; School of Animal and Veterinary Sciences, Faculty of Sciences, University of Adelaide, Roseworthy, SA 5371, Australia.; Dipartimento di Scienze Animali, della Nutrizione e degli Alimenti, Università Cattolica del Sacro Cuore, 29122 Piacenza, Italy., Minozzi G; Department of Veterinary Medicine DIMEVET, University of Milan, 20133 Milan, Italy. |
| Abstrakt: |
Johne's disease (JD) is caused by Mycobacterium avium subsp. paratuberculosis (MAP) and is an important and emerging problem in livestock; therefore, its control and prevention is a priority to reduce economic losses and health risks. Most JD research has been carried out on cattle, but interest in the pathogenesis and diagnosis of this disease in sheep and goats is greatest in developing countries. Sheep and goats are also a relevant part of livestock production in Europe and Australia, and these species provide an excellent resource to study and better understand the mechanism of survival of MAP and gain insights into possible approaches to control this disease. This review gives an overview of the literature on paratuberculosis in sheep and goats, highlighting the immunological aspects and the potential for "omics" approaches to identify effective biomarkers for the early detection of infection. As JD has a long incubation period before the disease becomes evident, early diagnosis is important to control the spread of the disease. |
